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Evaluations of different indicators of obesity and pro-inflammatory conditions in the follicular fluid of women with polycystic ovary syndrome
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Fatemeh Shirvanizadeh1    , Akram Eidi2 , Maryam Hafezi3 , Poopak Eftekhari-Yazdi4 |
1- PhD. Student, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Professor, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran , eidi@srbiau.ac.ir
3- Assistant Professor, Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
4- Associate Professor, Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran |
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Abstract: (846 Views) |
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and is considered a pro-inflammatory disease. Obesity is also a common pro-inflammatory phenotype in PCOS patients, which may play a role in the initiation or exacerbation of inflammation in PCOS patients. In this study, the role of various obesity indicators in increasing inflammation in the follicular fluid of PCOS patients has been investigated.
Materials and methods: 40 patients under 35 years were divided into two groups: PCOS and non-PCOS. Different obesity indices (body mass, neck circumference, arm circumference, and waist to hip circumference) were measured in each patient. Follicular fluid samples were collected from each patient. The concentration of tumor necrosis factor- α (TNF-α) in follicular fluid samples of patients was quantitatively evaluated using the ELISA method. The number of cumulus-oocyte complexes (COC) was recovered and their quality was scored.
Results: In the PCOS group, various obesity indices were significantly increased compared to the non-PCOS group (P ≤0.001). The concentration of TNF-α in the PCOS group was significantly higher than the other group (P<0.001). There were no significant differences in the number of retrieved COC per patient and the quality of oocytes between the groups (P>0.05).
Conclusion: Considering the important role of inflammation in the development of PCOS disease, management of obesity in PCOS patients may help to reduce inflammation and can potentially help to design personalized therapeutic approaches.
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| Keywords: Polycystic ovary syndrome, Obesity, Inflammation, Tumor necrosis factor-α. |
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Full-Text [PDF 382 kb]
(463 Downloads)
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Semi-pilot: case-control |
Subject:
Biology
Received: 2023/07/31 | Accepted: 2023/10/24 | Published: 2024/06/30
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Shirvanizadeh F, Eidi A, Hafezi M, Eftekhari-Yazdi P. Evaluations of different indicators of obesity and pro-inflammatory conditions in the follicular fluid of women with polycystic ovary syndrome. MEDICAL SCIENCES 2024; 34 (2) :155-162 URL: http://tmuj.iautmu.ac.ir/article-1-2149-en.html
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