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Evaluation of efficiency of some disinfectants in disinfection of water treatment system in the pharmaceutical industry and select the best one
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Ramin Asgharian1   , Asal Heidari2 , Ali Montaseri2 , Assem Abdollahpour3 , Saeed Ghiaee4 , Maryam Aminian5 |
1- PhD of Industrial Pharmacy, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran , ramin3205@gmail.com
2- Pharmacist, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
3- PhD of Analytical Chemistry, International Center for Science and High Technology and Environmental Science, Kerman, Iran
4- Pharmacist, Deputy of Control and Research, Jaber ebne Hayyan Pharmaceutical Company, Tehran, Iran
5- MSc of Microbiology, Chief of Microbial Control Laboratory, Jaber ebne Hayyan Pharmaceutical Company, Tehran, Iran |
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Abstract: (13228 Views) |
Background: Water used in the pharmaceutical industry should have special physicochemical and microbiological characteristics. One of the quality items of pharmaceutical water is level of microbial content. For this reason selection of effective disinfection method is the main item for design of pharmaceutical water systems. Water systems can be maintained at temperature below 10 ºC and more than 70 ºC but maintaining of water at ambient temperature could increase of microbial content. In this condition use of disinfectant is useful for reducing of microbial content. Some of them such as chloride, ozone and hydrogen peroxide due to good results have more application.
Materials and Methods: In this study, effect of three disinfectants chloride, ozone and hydrogen peroxide with 1 ppm concentration, consider on five microorganisms Pseudomonas aeruginosa, Staphylococcus aureus, candida albicans, Aspergillus niger and E.coli.
Results: Counting and decreasing of microorganisms showed the efficiency of disinfectants.
Conclusion: Finally ozone was selected as the best disinfectant due to high efficiency. |
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| Keywords: Pharmaceutical Water, Microbial control, Biofilm, Ozone, Cl2, H2O2 |
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Full-Text [PDF 185 kb]
(4441 Downloads)
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Semi-pilot: Experimental |
Subject:
Pharmacology
Received: 2013/09/22 | Published: 2013/09/15
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