Medical Sciences Journal of Islamic Azad University
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران
MEDICAL SCIENCES
Medical Sciences
http://tmuj.iautmu.ac.ir
1
admin
1023-5922
2008-3386
000
10.61882/iau
000
1023-5922
000
fa
jalali
1401
9
1
gregorian
2022
12
1
32
4
online
1
fulltext
fa
مروری بر نقش عوامل ژنتیکی میزبان در ابتلا به SARS-CoV-2
Review on the role of host genetic factors in the susceptibility to SARS-CoV-2
ژنتيك
Genetic
مروري
Review
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">سابقه و هدف</span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:Nazanin"><span style="font-weight:normal">:</span></span></span></i> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">همه گیری سندرم حاد تنفسی شدید نوع 2 (</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">SARS-CoV-2</span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">) بیش از یک سال است که تمام مردم دنیا را درگیر کرده است. بروز و شدت متفاوت این بیماری ویروسی در بین سنین مختلف و افراد با زمینه­های متفاوت بیماری می­تواند بیانگر نقش مهم عوامل ژنتیکی میزبان در میزان شیوع و مرگ و میر آنها باشد. به همین منظور مطالعه حاضر جهت مرور بر مهم­ترین عوامل و واریانت­های ژنتیکی دخیل در بروز و شدت بیماری </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">SARS-CoV-2</span></span></i><i><span style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> مطابق مطالعات انجام شده در جمعیت­های مختلف انجام شد</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">. </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal"></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.3pt">روش بررسی</span></span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.3pt"><span style="font-weight:normal">:</span></span></span></span></i> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">پایگاههای اطلاعاتی شامل</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Google Scholar </span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">،</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Bing </span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">،</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">PubMed Central </span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">PubMed</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">medRxiv</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">COVID-19 host genetics initiative</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> با استفاده از واژههای کلیدی </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Gene</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">polymorphism</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">disease severity</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Infection risk </span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">،</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Gene variant </span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Gene expression</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> برای یافتن مقالات مرتبط با فاکتورهای ژنتیکی همراه با </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">SARS-CoV-2</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و شدت آن مورد جستجو قرار گرفت.</span></span></span></span></i><i> </i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.3pt"><span style="font-weight:normal"></span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span lang="FA" style="font-weight: bold; font-size: 12pt;"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt">یافته </span></span></span><span lang="FA" style="font-size: 12pt;"><span style="font-family: "B Nazanin";"><span style="letter-spacing: -0.1pt;"><b>ها و نتیجه </b></span></span></span><span lang="FA" style="font-weight: bold; font-size: 12pt;"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt">گیری:</span></span></span> <i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">به نظر می­رسد علاوه بر واریانت­های سیستم </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">HLA</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> و ژن­های مرتبط با اینترفرون­ها نظیر </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">IFITM3</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">، ژن­های </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">TMPRSS2</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">، </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">ACE2</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">، </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">ACE</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">،</span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">CD147</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> و </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">TLR7</span></span></span></i><i style="font-weight: bold;"><span style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> مهم­ترین ژن­های دخیل در بیماریزایی ویروس </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">SARS-CoV-2</span></span></span></i><i style="font-weight: bold;"> </i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">هستند. بررسی مهم­ترین واریانت­های این ژن­ها در جمعیت­های مختلف در همراهی با </span></span></span></span></i><i style="font-weight: bold;"><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">SARS-CoV-2</span></span></span></i><i style="font-weight: bold;"><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> می­تواند راه را برای یافتن درمان­های هدفمندتر این بیماری فراهم آورد. به علاوه، با شناسایی این واریانت­ها می­توان در شناسایی سریع­تر حاملین پرخطر ویروس­های مشابه نسل­های بعدی گام­های موثرتری برداشت</span></span></span></span></i><i style="font-weight: bold;"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">. </span></span></span></span></i><span lang="FA" style="font-weight: bold; font-size: 12pt;"><span style="font-family:"B Koodak""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"></span></span></span></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Background</span></b><span style="font-size:11.0pt">: Severe acute respiratory system Cov-2 pandemic has affected the world populations for more than one year. Different incidence and severity of this viral disease among various age range and individuals with different background disease may indicate the pivotal role of host genetic factors in their prevalence and mortality rate. In this regards, present study was performed to review the most important genetic variants and factors in incidence and severity of SARS-CoV-2 based on the carried out studies in various populations. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Materials and methods</span></b><span style="font-size:11.0pt">: Databases including PubMed, PubMed Central, Google Scholar, Bing, medRxiv and COVID-19 host genetics initiative were explored using key words including gene polymorphism, gene expression, gene variant, infection risk and disease severity to find the papers regarding genetic factors association with SARS-CoV-2 and its severity. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Results and Conclusion</span></b><span style="font-size:11.0pt">: Its seems that in addition to the HLA system variants and the genes related to interferons as well as <i>IFITM3</i>, <i>ACE2, TMPRSS2</i>, <i>CD147, ACE</i> and <i>TLR7</i> genes are the most important genes which are involved in SARS-CoV-2 pathogenesis. Investigating the association of the most important genetic variants among different populations with SARS-Cov-2 can provide the way towards more targeted therapies for this disease. Moreover, by recognizing those variants, more efficient steps can be taken in early identification of the high risk carriers of the same next generation viruses.</span></span></span></span></span><br>
SARS-CoV-2, واریانت ژنی, پلی مورفیسم ژنی, شدت بیماری
SARS-CoV-2, Gene variant, Gene polymorphism, Disease severity
337
346
http://tmuj.iautmu.ac.ir/browse.php?a_code=A-10-908-2&slc_lang=fa&sid=1
Fatemeh
Karami
فاطمه
کرمی
fateme.karami@gmail.com
100319475328460010837
100319475328460010837
No
Department of Medical Genetics, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
گروه ژنتیک پزشکی، مرکز تحقیقات کاربردی بیوفتونیک، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، ایران
Mohammad Hossein
Modarressi
محمدحسین
مدرسی
modaresi@tums.ac.ir
100319475328460010838
100319475328460010838
Yes
Department of Medical Genetics, Faculty of Medicine, Tehran University Of Medical Sciences, Tehran, Iran
گروه ژنتیک پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران