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Association between HBe-Ag and HBV-DNA level in HBsAg positive chronic carriers
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Elaheh Ghaderi1    , Reza Salman Yazdi2 , Mehrangiz Zangeneh 3, Mahin Jamshidi Makiani4 , Masoumeh Mesgarian5 , Ali Sedighi Gilani5 |
1- General Practitioner, Medical Sciences Branch, Islamic Azad University, Tehran, Iran
2- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3- Department of Infectious Diseases, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran,Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , zangeneh4@yahoo.com
4- Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
5- Department of Infectious Diseases, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran |
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Abstract: (3515 Views) |
Background: Viral hepatitis is one of common infectious diseases and known as health problem around the world. Present cross-sectional study was performed to determine the association between HBeAg and HBV-DNA in patients who referred to Royan Institute for Reproductive Biomedicine and Amiralmomenin Hospital (Islamic Azad University) between 2012 and 2015.
Materials and methods: In this cross-sectional study, 222 patients were assessed and their HBe-Ag and HBV-DNA were analyzed by serological and molecular assays to determine the association between HBeAg and HBV-DNA for infectivity of infection. The results were gathered and recorded in the study checklist.
Results: 222 chronic HBsAg positive carriers, including 74 (33.2%) female and 148 (66.8%) male were studied. Of studied population, 10(6.8%) HBeAg positive, 108 (75.5%) HBeAb positive and 94 (42.34%) HBV DNA were detected. Level of detectable HBV-DNA was significantly higher in patients with HBeAg positive in compare with patients with negative HBe Ag (, P<0.001).
Conclusion: According to study findings, there is clinical association between HBe Ag positive and HBV-DNA level and we can use HBeAg for assessing the infectivity of HBV infection.
Keywords: HBV DNA, HBe Ag, HBe Ab, HBsAg |
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| Keywords: HBV DNA, HBe Ag, HBe Ab, HBsAg |
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Full-Text [PDF 400 kb]
(2111 Downloads)
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Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Microbiology
Received: 2018/05/26 | Accepted: 2018/12/11 | Published: 2019/06/16
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Ghaderi E, Salman Yazdi R, Zangeneh M, Jamshidi Makiani M, Mesgarian M, Sedighi Gilani A. Association between HBe-Ag and HBV-DNA level in HBsAg positive chronic carriers . MEDICAL SCIENCES 2019; 29 (2) :150-154 URL: http://tmuj.iautmu.ac.ir/article-1-1580-en.html
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