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:: Volume 29, Issue 2 (Summer 2019) ::
MEDICAL SCIENCES 2019, 29(2): 155-162 Back to browse issues page
The investigation of miR-499 in apoptosis of cardiomyocytes in blood serum of MI patients
Hesam Hasanzadeh1 , Changiz Ahmadizadeh 2, Abolfazl Ghorbani3
1- MSc, Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran
2- Department of Microbiology, Ahar Branch, Islamic Azad University, Ahar, Iran , ch-ahmadizadeh@iau-ahar.ac.ir
3- Department of Genetics, Shabestar Branch, Islamic Azad University, Shabestar, Iran
Abstract:   (3102 Views)
Background: Ischemic heart diseases (IHD) cause most deaths worldwide in a way that they are the cause of more than 30 percent of the deaths. After the discovery of miRNA in 1990 and the discovery of more than 2500 types of miRNA, gradually the importance of these mechanism regulators and molecular signals and gene routes were identified in the processes and the cellular mechanisms, especially in cardiovascular system. The goal of this research was to investigate miR-499 dominating the apoptosis of heart cellules in serums of the patients with MI (myocardial infarction).
Materials and methods: In this case-control study, miR-499 were investigated by real time PCR among 70 MI patients in Shahid Madani Hospital in Tabriz in 2017 and the data were compared with healthy persons. The statistical analyses were carried out using SPSS (version19) by t-test method. P<0.05 were considered as significant.
Results: The expression levels of miR-499 significantly increased among MI patients compared to control group (P=0.007). The miR-499 expression has no significant difference between overweight and normal weight people (P=0.06).
Conclusion: The present study showed that the expression of miR-499 among individuals suffering from MI has been greater than healthy people and it can be utilized as a diagnostic and also prognostic factor of MI patients.
Keywords: Acute myocardial infarction, Apoptosis, miR-499.
Keywords: Acute myocardial infarction, Apoptosis, miR-499.
Full-Text [PDF 878 kb]   (2020 Downloads)    
Semi-pilot: case-control | Subject: Microbiology
Received: 2018/09/8 | Accepted: 2018/11/27 | Published: 2019/06/18
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Hasanzadeh H, Ahmadizadeh C, Ghorbani A. The investigation of miR-499 in apoptosis of cardiomyocytes in blood serum of MI patients . MEDICAL SCIENCES 2019; 29 (2) :155-162
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Volume 29, Issue 2 (Summer 2019) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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