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:: Volume 30, Issue 3 (Fall 2020) ::
MEDICAL SCIENCES 2020, 30(3): 237-243 Back to browse issues page
Formulation and physicochemical control of vaginal suppositories containing the essential oil from Cuminum cyminum L. fruits
Atefeh Gholinejad Lindi1, Jinous Asgarpanah 2, Zahra Jafari Azar3
1- Pharmacist, Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
2- Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran , taxolfa@yahoo.com
3- Department of Pharmaceuticals, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Abstract:   (445 Views)
Background: Vulvovaginal candidiasis, as a prevalent vaginitis, is developed by Candida albicans. Regarding to the high incidence of this fungal infection and the antifungal activities of Cuminum cyminum, the preparation of vaginal suppositories containing its essential oil, has been considered as the main goal of the present investigation.
Materials and methods: The constituents of C. cyminum essential oil were identified by gas chromatography-mass spectrometry. The minimum inhibitory concentration (MIC) of the essential oil and the related formulation were determined by the cup plate method.
Results: Vaginal suppositories containing 0.1 ml of C. cyminum essential oil per suppository base (2 gr) (Polyethylene glycol) were prepared and their appearance, mass uniformity, hardness, disintegration time, content and uniformity were evaluated. The stability of suppositories containing C. cyminum essential oil stored at 4, 25 and 40°C was investigated after 1, 2, and 6 months. It was found that storage at lower temperatures (4 and 25°C) did not cause any damages to the formulation.
Conclusion: Due to the high quality of the formulated suppositories, it would be suggested as a successful replacement in the treatment of vaginitis caused by Candida albicans, after approving its efficacy in future clinical studies.
Keywords: Vulvovaginal candidiasis, Cuminum cyminum essential oil, Vaginal suppository
Full-Text [PDF 292 kb]   (343 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2019/07/27 | Accepted: 2019/08/10 | Published: 2020/09/20
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Gholinejad Lindi A, Asgarpanah J, Jafari Azar Z. Formulation and physicochemical control of vaginal suppositories containing the essential oil from Cuminum cyminum L. fruits. MEDICAL SCIENCES. 2020; 30 (3) :237-243
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Volume 30, Issue 3 (Fall 2020) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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