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:: Volume 31, Issue 1 (spring 2021) ::
MEDICAL SCIENCES 2021, 31(1): 88-96 Back to browse issues page
The comparison of the effect of dill extract and mefenamic acid on the duration of the postpartum pain: a randomized clinical trial
Fatemeh Kheiriyat1 , Mitra Tadayon Najafabadi 2, Parvaneh Mousavi3 , Mohamad Hossain Haghighizadeh4 , Foroogh Namjoyan5
1- Msc in Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
2- Instructor, Department of Midwifery, Menopause Andropause Research Center, School of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , mitratadayon2000@yahoo.com
3- Instructor, Department of Midwifery, Reproductive Health Research Center, School of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
4- Instructor, Department of Statistics, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Assistant Professor, Department of Pharmacognosy, School of Pharmacology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (2215 Views)
Background: Postpartum pain is one of the problems of the Post-delivery period. Prostaglandin inhibitors, such as nonsteroidal anti-inflammatory drugs, are commonly used to reduce pain, but may cause gastrointestinal side effects. In this study, the effect of dill essential oil and mefenamic acid on the duration of postpartum pain was compared.
Materials and methods: 108 multiparous women who had a normal vaginal delivery and suffered from the postpartum pain were recruited from Razi hospital of Ahvaz City. Subjects were randomly divided into two groups of 54: dill essential oil (1.5 mg / kg) and mefenamic acid (250 mg capsule), using a simple random sampling method. The magnitude of postpartum pain was measured by the Visual Analogue Scale two hours after birth. Patients experiencing the pain of 3.1 and more enrolled in the study. Both extract and mefenamic acid administered every 6 hours up to 4 times in case of constant pain. Following consumption of dill extract or mefenamic acid, the patient was asked to mention the duration of drug effect, the time of complete removal of the pain and the time of experiencing pain resumption. Statistical analysis was was done by t-test, Chi-square and repeated measure using SPSS Statistics V22.
Results: The duration of pain has decreased significantly over the time (39.2±3.21 and 32.07±1.89 min for the first and fourth intervention of dill extract, and 40.5±4.09 and 31.97±3.15 min for the first and fourth intervention of mefenamic acid) (P<0.001).The mean duration of drug effect following second and third intervention showed a significant reduction in the extract group (19.24±2.05 and 20.89±2.74 min respectively) compared to mefenamic acid group (34.22± 85.3 and 21.12±3.55 min respectively) (P<0.005).
Conclusion: It bseems that the onset of action of dill extract is faster than mefenamic acid; so extract can be used due to the lack of gastrointestinal side effects.
Keywords: Anethum graveolens, Postpartum care, pain, Mefenamic Acid.
Full-Text [PDF 348 kb]   (1264 Downloads)    
Semi-pilot: Controlled/Randomized clinical trial | Subject: Midwifery
Received: 2020/04/11 | Accepted: 2020/06/14 | Published: 2021/03/24
References
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25. 25)Goncalves JC, Oliveira Fde, Benedito RB, De Sousa DP and et al. Antinococeptive activity of (-) carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull 2008; 31(5): 1017-20. [DOI:10.1248/bpb.31.1017]
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29. 29) Ebrahimzadeh Zagami S, Golmakani N, Kabirian M, Taghi Shakari M. Effect of Dill (Anethum graveolens Linn.) Seed on uterus contraction pattern in avtive phase of labor. Indian J Tradit Know 2012; 11(4):602-6.
30. 30)Hekmatzadeh SF, Mirmolaei ST, Hoseini N. The Effect of Boiled Dill (Anethum graveolens) Seeds on the Long Active Phase and Labor Pain Intensity. Armaghane-danesh 2011; 67: 50-9.
31. 31)Mohammadinia N, Rezaei MA, Salehian T, Dashipour AR. Comparing the effect of Anethum gravolens with mefenamic acid consumption on treatment of primary dysmenorrheal. J Shahrekord Univ Med Sci 2013; 15(5):57-64.
32. 32)Mojalli M, Basiri Moghadam M, Shamshiri M. Effectiveness of Instructional Environment and Related Factors on Breastfeeding Function of Mothers. Ofogh-e-Danesh. GMUHS J 2010; 16(1): 59-64.
33. 33)Andalibi B, Zehtab Salmasi S, Ghassemi Gholezani K, Saba J. Changes in Essential Oil Yield and Composition at Different Parts of Dill (Anethum graveolens L.) Under Limited Irrigation Conditions 2011;21(2): 12-22.
34. 34)Hekmatzadeh SF, Bazarganipour F, Malekzadeh J, Goodarzi F, Aramesh S. A randomized clinical trial of the efficacy of applying a simple protocol of boiled Anethum Graveolens seeds on pain intensity and duration of labor stages. Complement Ther Med 2014; 22(6):970-6. [DOI:10.1016/j.ctim.2014.10.007]
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37. 37) Jafari S, Mehdizadeh A, Ghavamzadeh S. The Effect of Two Different Doses of Cuminum Cyminum Extract on Serum Glycemic Indices and Inflammatory Factors in Patients with Diabetes Type II: A Randomized Double-Blind Controlled Clinical Trial. J Ardabil Univ Med Sci 2016;16(2):200-10.
38. Deussen AR, Ashwood P, Martis R, Eds. Analgesia for relief of pain due to uterine cramping/involution after birth. New York: The Cochrane Library; 2011. [DOI:10.1002/14651858.CD004908.pub2]
39. Dox I, Melloni JL, Sheld HH, Eds. Melloni's illustrated dictionary of obstetrics and gynecology. 6th ed. New York: Parthenon Pub Group; 2000.
40. Cunningham F, Leveno K, Bloom S, Spong CY, Dashe J, Eds. Williams obstetrics. 24th ed. New York: McGraw- Hill; 2014.
41. Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe J, Hoffman B, Casey B, eds. Williams obstetrics. 25 th ed. New York: McGraw-Hill; 2018.
42. Holdcraft A, Snidvongs S, Cason A, J Doré C, Berkley K. Pain and uterine contractions during breast feeding in the immediate post-partum period increase with parity. Pain 2003; 104: 589-96. [DOI:10.1016/S0304-3959(03)00116-7]
43. Soltani P, Parsay S, eds. Maternal and child health. 2th ed. Tehran: Sanjesh Publishers; 2005. [In Persian]
44. Jangsten E, Bergh I, Mattsson LA, Hellstron AL and Berg M. Afterpains: a comparison between active and expectant management of the third stage of labor. Birth 2011; 38: 294 - 301. [DOI:10.1111/j.1523-536X.2011.00487.x]
45. Eisenach JC1, Pan PH, Smiley R, Lavand'homme P, et al. Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression. Pain 2008; 140: 87-94. [DOI:10.1016/j.pain.2008.07.011]
46. Azmoudeh E, Azizi S, Fazel N. The severity of acute postpartum pain, regardless of the type of delivery, predicts persistence in chronic pain and depression. Beyhagh; Journal Of Sabzevar School Of Medical Sciences 2009; 19: 25-31. [In Persian]
47. Ozgoli G, Khodadadie A, Sheikhan Z, Jambarsang S, Mojab F, Taleb S. Comparison of efficacy between herbal capsule of anise and mefenamic acid on after-pain. J Med Plants 2017; 2:38-49.
48. Chenanh M, Janati Ataei P, Dolatian M, Mojab F, Nasiri M. Comparison of the Combined Effect of Nigella Sativa and Mefenamic Acid with Mefenamic Acid alone on after pain in Multiparous Women: A Double-blind Clinical Trial Study. Iran J Obstet Gynecol Infertil 2018;4:62-71.
49. Fazel N, Esmaeeli H. Eeffect of Caminum cyminum on pain severity after cesarean. J Iran Obstet Gynecol Infertil 2010; 11: 23-9. [In Persian]
50. Pillitteri A, Ed. Maternal & child health nursing: care of the childbearing & childrearing family. Philadelphia: Lippincott Williams & Wilkins; 2010.
51. Katzung BG, Masters SB, Trevor AJ, Eds. Basic & clinical pharmacology. New York: McGraw-Hill Medical; 2016.
52. Shakiba Dastgerdi A, Rafieian- kopaei M, Jivad, Sedehi M. Effect of hydroalcoholic extract of Anethum graveolens leaves on time response to pain stimuli in mice. J Shahrekord Univ Med Sci 2013; 15: 70-76. [In Persian]
53. Pillitteri A, Ed. Maternal & child health nursing. 6th ed. philadelphia: Lippincott Williams & wilkin; 2008. P.426-34.
54. Qi Z, Kelley E. The WHO traditional medicine strategy 2014-2023: a perspective. Science 2014; 346:S5-6.
55. Golian Tehrani Sh, Mirmohammadali M, Soltani Moghadam A, Mehran A, Taghi Zadeh M, Baleghi M. The Comparison of Fennel and Mefenamic Acid Effects on Post-Partum after Pain. J Babol Univ Med Sci 2015; 17: 7-13. [In Persian]
56. Shadipour M, Simbar M, Salamzadeh J, Nasire N. A comparative study on the effects of Menstrogol and Mefenamic acid on postpartum after-pain. Iran South Med J 2014; 16:401-9. [In Persian]
57. Pourmaleky S, Najar SH, Montazery S, Haghighizadeh MH. A Comparison between the effects of Zintoma (Ginger) and Mefenamic acid on after pain during postpartum in multiparous women. Iran J Obstet Gynecol Infertil 2013; 16:18-25. [In Persian]
58. Tafazoli M, Khadem Ahmad Abadi M, Asily J, Esmaili H. A comparative study on the effects of Cuminum Cyminum and Mefenamic acid on postpartum after-pain in Vomen Multipar. The Iranian Journal of Obstetrics, Gynecology and Infertility (IJOGI) 2013; 16:1-11. [In Persian]
59. Shakeri Hosseinabad S, Shabanian GH, Shabanian SH, Rafiean M, Kheiri S, Lorigooini Z, et al. Evaluating the Effect of Dill (Anethum graveolens L.) Seed Essence on Pain and Vital Sign of Cesarean Delivery with Spinal Anesthesia. J Ardabil Univ Med Sci 2017;17: 311-23. [In Persian]
60. Hatami K, Yousofvand N, Sayadi F. Eefect of dill ethanol extract on pain and morphine- induced analgesia in male mice. Urmia Med J 2015; 26: 594.601. [In Persian]
61. Cheraghi J, Valadi A. The analgesic and anti-inflammatory effect of limonene compounds found in medicinal plants. Med Aromatic Plants Res J 2005; 3: 415-22.
62. Gonçalves JC, Oliveira Fde S, Benedito RB, de Sousa DP, de Almeida RN, de Araújo DA. Antinococeptive activity of (-) carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull 2008; 31: 1017-20. [DOI:10.1248/bpb.31.1017]
63. Rajabi Naeeni M, Modarres M, Amin GH, Bahrani N. A Comparative Study of the Effects of Cumin and Mefenamic Acid Capsules on Secondary Dysmenorrhea Due to IUD: A Randomized Triple Blind Clinical Trial. Complement Med J Fac Nurs Midwifery 2013; 3: 563-73. [In Persian]
64. Da Rocha ML, Oliveira LEG, Patrı'cio Santos CCM, de Sousa DP, de Almeida RN, Arau'jo DAM. Antinociceptive and anti-inflammatory effects of the monoterpene α,β-epoxy-carvone in mice. J Nat Med 2013; 67:743-9. [DOI:10.1007/s11418-012-0738-8]
65. Monsefi M, Gramifar F. Effects of aqueous fraction of Anethum graveolens L. (dill) extracts on fertility and terminal sugar of female rat's reproductive system. J Birjand Univ Med Sci 2013; 19 : 362- 375. [In Persian]
66. Ebrahimzadeh Zagami S, Golmakani N, Kabirian M, Taghi Shakari M. Effect of Dill (Anethum graveolens Linn.) Seed on uterus contraction pattern in avtive phase of labor. Indian J Tradit Know 2012; 11:602-6.
67. Hekmatzadeh SF, Mirmolaei ST, Hoseini N. The Effect of Boiled Dill (Anethum graveolens) Seeds on the Long Active Phase and Labor Pain Intensity. Armaghane-danesh 2011; 67: 50-9. [In Persian]
68. Mohammadinia N, Rezaei MA, Salehian T, Dashipour AR. Comparing the effect of Anethum gravolens with mefenamic acid consumption on treatment of primary dysmenorrheal. J Shahrekord Univ Med Sci 2013; 15:57-64. [In Persian]
69. Mojalli M, Basiri Moghadam M, Shamshiri M. Effectiveness of Instructional Environment and Related Factors on Breastfeeding Function of Mothers. Ofogh-e-Danesh. GMUHS J 2010; 16: 59-64. [In Persian]
70. Andalibi B, Zehtab Salmasi S, Ghassemi Gholezani K, Saba J. Changes in Essential Oil Yield and Composition at Different Parts of Dill (Anethum graveolens L.) Under Limited Irrigation Conditions Journal of Agricultural Science (University Of Tabriz) 2011;21: 12-22. [In Persian]
71. Hekmatzadeh SF, Bazarganipour F, Malekzadeh J, Goodarzi F, Aramesh S. A randomized clinical trial of the efficacy of applying a simple protocol of boiled Anethum Graveolens seeds on pain intensity and duration of labor stages. Complement Ther Med 2014; 22:970-6. [DOI:10.1016/j.ctim.2014.10.007]
72. Honarvar F. The effect of Fenoculum vulgrate on serum prolactin level in lactating women. The Iranian Journal of Obstetrics, Gynecology and Infertility (IJOGI) 2013;16:18-24.
73. Moslemi L, Bekhradi R, Hassani S, Khaleghi Nejad Kh. Effect of Foeniculum vulgare on primary dysmenorrhea. J Fam Health 2013;1:15-20.
74. Jafari S, Mehdizadeh A, Ghavamzadeh S. The Effect of Two Different Doses of Cuminum Cyminum Extract on Serum Glycemic Indices and Inflammatory Factors in Patients with Diabetes Type II: A Randomized Double-Blind Controlled Clinical Trial. J Ardabil Univ Med Sci 2016;16:200-10. [In Persian]
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Kheiriyat F, Tadayon Najafabadi M, Mousavi P, Haghighizadeh M H, Namjoyan F. The comparison of the effect of dill extract and mefenamic acid on the duration of the postpartum pain: a randomized clinical trial. MEDICAL SCIENCES 2021; 31 (1) :88-96
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Volume 31, Issue 1 (spring 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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