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:: Volume 31, Issue 2 (summer 2021) ::
MEDICAL SCIENCES 2021, 31(2): 156-163 Back to browse issues page
The effect of curcumin on altered expression of BAX and BCL2 genes following cholestasis in the frontal region of male rats
Shabnam Akbari1 , Mohammad Nasehi 2, Mehrdad Hashemi3
1- MSc,Department of Genetics,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran
2- Associate Professor,Department of Physiology,Institute for Cognitive Science Studies(ICSS),Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , Nasehi@iricss.org
3- Professor,Department of Genetics,Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:   (1987 Views)
Background: Cholestasis occurs as a result of malfunction or secretion of bile; and complications of this disease include apoptosis (planned death). Curcumin is an effective extract of turmeric rhizome that has anti-apoptosis properties. Thus in this study, we investigated the expression of BAX and BCL2 genes following cholestasis and curcumin in the frontal region of male rats.
Materials and methods: This study was performed on 16 male rats weighing 220-240 gram in which they were divided into 4 groups, including control group, sham-curcumin, BDL group and BDL-curcumin. Then peripheral region of rats was collected and after extraction of RNA and cDNA synthesis, expression of genes in different groups was evaluated by Real Time PCR technique.
Results: BCL2 gene expression decreased in the BDL group compared to the control group(p<0.05), and BAX gene expression increased in the BDL group compared to the control group as a result,the cell progresses to apoptosis. However,with the injection of curcumin,the expression of BCL2 gene in the BDL-Curcumin group increased compared the BDL group and BAX gene expression decreased  in the BDL-Curcumin compared to the BDL group.
Conclusion: Curcumin can increase the expression of BCL2 gene and decrease the expression of BAX gene in the frontal region,reduce the negative effects of cholestasis including apoptosis.
Keywords: Cholestasis, Bax, Bcl2, Curcumin, Frontal
Full-Text [PDF 497 kb]   (1340 Downloads)    
Semi-pilot: Basic | Subject: Brain and Nerves System
Received: 2020/06/16 | Accepted: 2021/01/10 | Published: 2021/06/22
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Akbari S, Nasehi M, Hashemi M. The effect of curcumin on altered expression of BAX and BCL2 genes following cholestasis in the frontal region of male rats. MEDICAL SCIENCES 2021; 31 (2) :156-163
URL: http://tmuj.iautmu.ac.ir/article-1-1708-en.html


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Volume 31, Issue 2 (summer 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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