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:: Volume 31, Issue 1 (spring 2021) ::
MEDICAL SCIENCES 2021, 31(1): 121-127 Back to browse issues page
The association of serum omentin-1 levels with biochemical parameters in patients with nonalcoholic fatty liver disease
Neda Kolivand Saloki1, Mahnaz Mohammadi 2, Masoumeh Nejdadali3, Tahereh Nagi4
1- MSc, Department of Biotechnology, Tehran medical sciences,Islamic Azad University,Tehran,Iran
2- Assistant Professor, Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran , mh_mohamadi@yahoo.com
3- Assistant Professor, Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
4- Associate professor, Department of Biology, Tehran medical sciences,Islamic Azad University,Tehran,Iran
Abstract:   (549 Views)
Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing due to the growing epidemics of obesity. Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. The aim of this study was to determine omentin-1 serum levels and its relationship with body mass index, fasting blood sugar and lipid profile.
Materials and methods: This case-control study was performed on 70 patients with non-alcoholic fatty liver disease and 70 participants as controls. Plasma levels of omentin 1 were measured by ELISA kit and other variables were determined by standard methods. Data were analyzed using SPSS version 20 software.
Results: Patients with non-alcoholic fatty liver presented significantly higher omentin levels compared to the controls (p<0.05). NAFLD patients had significantly higher levels of body mass index (BMI) and triglycerides, compared to healthy group (p-value<0.05). An inverse correlation was observed between omentin1with BMI, triglyceride, and LDL-C (p<0.05), but were positively associated with HDL‑C levels (p<0.05). We did find correlation between omentin‑1 with FBS in patients with non-alcoholic fatty liver (p<0.05).
Conclusion: The findings showed that omentin-1 serum levels were significantly different in patients with NAFLD when compared to controls. Omentin levels are correlated with BMI, LDL-C, and HDL-C.
Keywords: omentin, Lipid profile, Non-alcoholic fatty liver disease, Anti-inflammatory
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Semi-pilot: Experimental | Subject: Cilinical Biochemistry
Received: 2020/05/19 | Accepted: 2020/09/5 | Published: 2021/03/18
References
1. Rezaie F, Nezhadali M, Hedayati M. Association of adiponectin rs17300539 gene polymorphism with a nonalcoholic fatty liver disease in an Iranian population. Feyz 2018; 22: 387-94. [In Persian]
2. Rabiee S, Nezhadali M, Hedayati M. Association of Adiponectin Gene rs2241766 Polymorphism with non-Alcoholic Fatty Liver Disease in an Iranian Population. Armaghane-danesh, YUMSJ 1397; 23: 476-487. [In Persian]
3. Kohan L, Safarpur M, Abdollahi H. Omentin-1 rs2274907 and resistin rs1862513 polymorphisms influence genetic susceptibility to nonalcoholic fatty liver disease. Mol Biol Res Commun 2016; 5:11-17.
4. Aliasghari F, Izadi A, Jabbari M, Imani B, Pourghassem Gargari B, Asjodi F, et al. Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients? J Med Biochem 2018; 37: 470-475. [DOI:10.2478/jomb-2018-0006]
5. Zhang Y, Yang C, Hao Z, Shen X, Zhou J, Zhang L, Liang C. Circulating levels of adipocytokines omentin-1 and adiponectin in patients with bladder can. Int J Clin Exp Pathol 2016; 9:11718-11726.
6. Khadem Ansari MH, Gholamnejad M, Meghrazi K, Khalkhali HR. Association of circulating omentin-1 level with lung cancer in smokers. Med J Islam Repub Iran. 2018; 32:1-5. [DOI:10.14196/mjiri.32.133]
7. Zhou Y, Zhang B, Hao C, Huang X, Li X, Huang Y.et al. Omentin-A Novel Adipokine in Respiratory Diseases. Int J. Mol Sci 2018; 19:1-16 [DOI:10.3390/ijms19010073]
8. Aleksandrova K, Giuseppe R D, Isermann B, Biemann R, Schulze M, Wittenbecher C, et al. Circulating omentin as a novel biomarker for colorectal cancer risk: data from the EPIC-Potsdam cohort study. Cancer Res 2016; 76:3862-3871. [DOI:10.1158/0008-5472.CAN-15-3464]
9. Wu D-M, Wang S, Wen X, Han X-R, Wang Y-J, Shen M, et al. Impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke. Am J Transl Res 2019; 11:1854-1863.
10. Alizadeh S, Mirzaei K, Mohammadi C, Keshavarz S A, Maghbooli Z. Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size. Arch Endocrinol Metab 2017; 61:567-74. [DOI:10.1590/2359-3997000000269]
11. Halabis M, Dziedzic M, Warchulinska J, Iwona Kaznowska-Bystryk I, Solski J. Omentin - a new adipokine with many roles to play. Curr Issues Pharm Med Sci. 2015; 28: 176-180. [DOI:10.1515/cipms-2015-0067]
12. Lesná J, Tichá A, Hyšpler R, Musil F, Bláha V, Sobotka L, et al. Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus type 1: impact of weight reduction. Nutr Diabetes 2015; 5: 1- 6. [DOI:10.1038/nutd.2015.33]
13. Montazerifar F, Bakhshipour AR, Karajibani M, Torki Z, Dashipour AR. Serum omentin 1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease. J Res Med Sci 2017; 22:1-7. [DOI:10.4103/jrms.JRMS_788_16]
14. Waluga M, Kukla M, Zorniak M, Kajor M, Liszka L, Dyaczynski M. Fibroblast growth factor-21 and omentin-1 hepatic mRNAexpression and serum levels in morbidly obese women with non- alcoholic fatty liver. J Physiol Pharmacol 2017; 68:363-374.
15. Loomba R, Quehenberger O, Armando A, Dennis EA. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res 2015; 56: 185-92. [DOI:10.1194/jlr.P055640]
16. Karimi H, Nezhadali M, Hedayati M. Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population. Endocr Regul 2018; 52: 176-184. [DOI:10.2478/enr-2018-0022]
17. Kalayci D, Konuk S, TugT. Serum Omentin Levels in Asthma Patients. Arch Clin Biomed Res 2018; 2: 052-058. [DOI:10.26502/acbr.5017041]
18. Tahmasebpour N, Hosseinpour Feizi MA, Ziamajidi N, Pouladi N, Montazeri V, Farhadian M, et al. Association of Omentin-1 with Oxidative Stress and Clinical Significances in Patients with Breast Cancer. Adv Pharm Bull 2020; 10: 106-113. [DOI:10.15171/apb.2020.013]
19. Nourbakhsh P, Ganji A, Farahani I , Hosseinian P, Yeganefard F, Mirzaee R, et al. Adipokine Omentin-1: A Diagnostic Tool in Breast Cancer. Int J Med Sci 2018; 3:89-93. [DOI:10.15171/ijbsm.2018.16]
20. Wei X, Wei S, Kong Y, Tian S, Wang W, Jiang. Association of serum omentin and adiponectin levels with the occurrence of liver cirrhosis. Int J Clin Exp Med 2017; 10:5011-5019.
21. 1.Dyson JK, Anstee QM, McPherson S. Non-alcoholic fatty liver disease:a practical approach to treatment. Frontline Gastroenterol 2014; 5: 277-286. [DOI:10.1136/flgastro-2013-100404]
22. Rashad MN, Gomaa AF, Abomandour HG, Ibrahim EM, Hasan MM. The association of serum omentin-1 levels with severity of nonalcoholic fatty liver disease in correlation with cardiovascular risk factors among Egyptian women. Med J Cairo Univ 2019; 87:1-14. [DOI:10.21608/mjcu.2019.53966]
23. Jialal I, Devaraj S, Kaur H, Bremer AA. Increased Chemerin and Decreased Omentin-1 in Both Adipose Tissue and Plasma in Nascent Metabolic Syndrome. J Clin Endocrinol Metab 2013;9: 514-E517. [DOI:10.1210/jc.2012-3673]
24. Jha CK, Mir R, Elfaki I, Javid J, Babakr AT, Banu S,et al. Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study. J Pers Med 2019; 9: 1-11. [DOI:10.3390/jpm9020030]
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Kolivand Saloki N, Mohammadi M, Nejdadali M, Nagi T. The association of serum omentin-1 levels with biochemical parameters in patients with nonalcoholic fatty liver disease. MEDICAL SCIENCES. 2021; 31 (1) :121-127
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Volume 31, Issue 1 (spring 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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