LncRNAs are non-coding transcripts with more than 200 nucleotides in length which interact to other molecules through their particular molecular structures and affect on numerous molecular processes. Key functions of lncRNAs in a great variety of cell pathways have been significantly studied. These molecules are expressed in many various cell types, but their decreased or increased expression has been reported in different diseases, especially cancer. Published papers have introduced lncRNAs and their crucial roles in primary steps of tumorigenesis, tumor development and apoptosis. lncRNAs importance in cancer occurrence is so remarkable that level measurement of some of them may be a considerable aid in diagnosis or prognosis of related cancer. Furthermore, a variety of new therapeutic approaches are innovated based on inhibition or enhancement of lncRNAs functions for alleviation disease severity however, they are conceivable only in research concept. In the current article, these approaches and their related molecular basis are conveyed by the use of the newest reliable resources.

Keywords: long non-coding RNAs, Cancer, Tumorogenesis, Treatment.