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The study of the effects of formaldehyde injection on testicular tissue structure of mouse
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Zahra Toutian   1, Mohammadtaghi Sheybani , Simin Fazelipour , Mehdi Taghavi |
| 1- , tootianz@ut.ac.ir |
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Abstract: (17805 Views) |
Background: Formaldehyde is one of the chemicals which are widely used in different places. Considering the fact that the usage of this chemical can induce a reduction on the motility and viability of spermatozoa and/or make them abnormal, a precise study on testicular tissue structure, producing spermatozoa, seems to be necessary because no accurate study has previously been carried out on this issue.
Materials and Methods: In this experimental-quantitative investigation, a total number of 30 mice were divided into four experimental and one control groups. In this study, formaldehyde has been injected intraperitoneally at different doses for a period of time of 40 days. In order to provide the tissue specimens, the mice were initially anesthetized and after removing the testes and tissue preparing processes, the hematoxylin and eosin staining method was used and the sections of testicular tissue were studied under light microscope.
Results: Comparison to the control group, disorganization in some seminiferous tubules, cellular irregularity and reduction in density of genital cells, increasing of intertubular spaces, and confusion of interstitial tissue, discoloration and vacuolization of leydig cell cytoplasm and also a thickness in basement membrane of spernatogenic epithelium were observed in the experimental groups.
Conclusion: The results of this study revealed that injective formaldehyde could induce some changes in testicular tissue and also it could increase the risk of infertility. |
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| Keywords: Formaldehyde, Testicular tissue, Mouse, Infertility, Sperm. |
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Full-Text [PDF 483 kb]
(2224 Downloads)
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Subject:
Epidemiology
Received: 2006/09/6 | Published: 2006/09/15
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