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:: Volume 28, Issue 1 (spring 2018) ::
MEDICAL SCIENCES 2018, 28(1): 16-23 Back to browse issues page
The effect of sodium butyrate, histone deacetylase inhibitor on spatial learning and memory in rat model of cerebral hypoxic-ischemia
Mohammad Amin Edalatmanesh *1, Samira Sahraeian2, Samaneh Rafiei3
1- Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
2- Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3- Ph.D. Candidate in Biochemistry and exercise metabolism, Department of Exercise Physiology, Kish International Campus, Tehran University, Kish, Iran
Abstract:   (1353 Views)
Background: Cerebral ischemic stroke is the third cause of death in developed countries and is one of the main causes of long-term disabilities. This study investigated the effect of sodium butyrate, as histone deacetylase inhibitor (HDAI), on spatial learning and memory in cerebral hypoxic ischemia (HI) model.
Materials and methods: In this experimental study, fifty male rats were divided into control, HI+Saline, HI+SB 0.1, HI+SB 0.3, and HI+SB 0.6 groups. In order to induce HI model, after permanent left carotid artery closure, the rats was placed in the hypoxic chamber (8% oxygen) for 1 hour. 24 hours after surgery, based on rats' weight sodium butyrate was injected at doses of 0.1, 0.3 and 0.6 mg/ kg as intra-peritoneal for 14 days. Rats in HI+Saline group were received normal saline for 14 days. Spatial memory in these groups was studied by Morris water maze (MWM) test. Then, the hippocampal level of BDNF was measured using ELISA.
Results: However, HI+Saline group had a longer latency time to find hidden platform in MWM test, the results indicated improved spatial memory or decreased latency time to find hidden platform in MWM in rats received sodium butyrate. In spite of decreasing the hippocampal level of BDNF in the HI+Saline rats, this factor significantly increased in SB-treated rats.
Conclusion: Sodium butyrate is able to improve spatial learning and memory in cerebral hypoxic ischemia model.
Keywords: Hypoxia-ischemia, Histone deacethylase inhibitors, Spatial memory, Morris water maze, Rat.
Full-Text [PDF 376 kb]   (299 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2017/01/11 | Accepted: 2017/04/10 | Published: 2018/04/1
1. Altug EM, Melek IM, Erdoğan S, Düzgüner V, Öztürk A, Küçükgül A. The Neuroprotective Effect of Caffeic Acid Phenethyl Ester on Global Ischemia-Reperfusion Injury in Rat Brains. Kafkas Uni Vet Fak Derg 2014;20:877-84.
2. Ahmadiasl N, Alaei H, Hänninen O. Effect of exercise on learning, memory and levels of epinephrine in rats' hippocampus. J Sports Sci Med 2003;2:106-9.
3. Dröse S, Stepanova A, Galkin A. Ischemic A/D transition of mitochondrial complex I and its role in ROS generation. Biochim Biophys Acta 2016;1857:946-57. [DOI:10.1016/j.bbabio.2015.12.013]
4. Ułamek-Kozioł M, Pluta R, Bogucka-Kocka A, Januszewski S, Kocki J, Czuczwar SJ. Brain ischemia with Alzheimer phenotype dysregulates Alzheimer'sdisease-related proteins. Pharmacol Rep 2016;68:582-91. [DOI:10.1016/j.pharep.2016.01.006]
5. Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. ILAR J 2014;55:310-32. [DOI:10.1093/ilar/ilu013]
6. Yashiro K, Philpot BD. Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology 2008;55:1081-94. [DOI:10.1016/j.neuropharm.2008.07.046]
7. Claesson L, Lindén T, Skoog I, Blomstrand C. Cognitive impairment after stroke- impact on activities of daily living and costs of care for elderly people. The Göteborg 70+ Stroke Study. Cerebrovasc Dis 2005;19:102-9. [DOI:10.1159/000082787]
8. Chang JG, Hsieh-Li HM, Jong YJ, Wang NM, Tsai CH, Li H. Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A 2001;98:9808-13. [DOI:10.1073/pnas.171105098]
9. Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci 2003;23:9418-27. [DOI:10.1523/JNEUROSCI.23-28-09418.2003]
10. Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 2012;64:238-58. [DOI:10.1124/pr.111.005108]
11. Rafiei S, Bazyar Y, Edalatmanesh MA. Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration. Shefaye Khatam 2016;4:1-6. [DOI:10.18869/acadpub.shefa.4.1.1]
12. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004;20:2580-90. [DOI:10.1111/j.1460-9568.2004.03720.x]
13. Hosono T, Kamo A, Hakotani S, Minato K, Akeno H, Taguchi Y, et al. Effect of hypothermia on motor function of adult rats after neonatal hyperthermic hypoxic-ischemic brain insult. Eur J Appl Physiol 2010;109:35-9. [DOI:10.1007/s00421-009-1156-9]
14. Golestani S, Edalatmanesh MA, Hosseini M. The Effects of Sodium Valproate on Learning and Memory Processes in Trimethyltin Model of Alzheimer's Disease. Shefaye Khatam 2014;2:19-26.
15. Moghadas M, Edalatmanesh MA. The Lithium Chloride Effect on Anxiety, Exploratory Activity, and Brain Derived Neurotrophic Factor Levels of the Hippocampus in a Rat Model of TMT Intoxication. Shefaye Khatam 2015;3:1-10. [DOI:10.18869/acadpub.shefa.3.2.1]
16. Tian L, Nie H, Zhang Y, Chen Y, Peng Z, Cai M, et al. Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice. Neuropharmacology 2014;77:453-64. [DOI:10.1016/j.neuropharm.2013.10.027]
17. Squire LR, Wixted JT. The cognitive neuroscience of human memory since H.M. Annu Rev Neurosci 2011;34:259-88. [DOI:10.1146/annurev-neuro-061010-113720]
18. Taliyan R, Ramagiri S. Delayed neuroprotection against cerebral ischemia reperfusion injury: putative role of BDNF and GSK-3β. J Recept Signal Transduct Res 2016;36:402-10. [DOI:10.3109/10799893.2015.1108338]
19. Nykjaer A, Willnow TE, Petersen CM. p75NTR--live or let die. Curr Opin Neurobiol 2005;15:49-57 [DOI:10.1016/j.conb.2005.01.004]
20. Yano H, Chao MV. Mechanisms of neurotrophin receptor vesicular transport. J Neurobiol 2004;58:244-57. [DOI:10.1002/neu.10321]
21. Opitz B, Mothes HK, Clausing P. Effects of prenatal ethanol exposure and early experience on radial maze performance and conditioned taste aversion in mice. Neurotoxicol Teratol 1997;19:185-90. [DOI:10.1016/S0892-0362(96)00225-5]
22. Forrest MD. The sodium-potassium pump is an information processing element in brain computation. Front Physiol 2014;5:472. [DOI:10.3389/fphys.2014.00472]
23. Chand DM, Leng Y, Mariova Z, Kim HJ, Chiu CT. Multipe roles of HDAC hippocampal neurodegenerative conditions. Science Direct 2009;11:591-601.
24. Liu RR, Murphy TH. Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study. J Biol Chem 2009;284:36109-17. [DOI:10.1074/jbc.M109.055301]
25. Fathallah H, Atweh GF. Induction of fetal hemoglobin in the treatment of sickle cell disease. Hematology Am Soc Hematol Educ Program 2006:58-62. [DOI:10.1182/asheducation-2006.1.58]
26. Park MJ, Sohrabji F. The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflammation 2016;13:300. [DOI:10.1186/s12974-016-0765-6]
27. Ziemka-Nalecz M, Jaworska J, Sypecka J, Polowy R, Filipkowski RK, Zalewska T. Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia. Mol Neurobiol 2017;54:5300-18. [DOI:10.1007/s12035-016-0049-2]
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Edalatmanesh M A, sahraeian S, Rafiei S. The effect of sodium butyrate, histone deacetylase inhibitor on spatial learning and memory in rat model of cerebral hypoxic-ischemia. MEDICAL SCIENCES. 2018; 28 (1) :16-23
URL: http://tmuj.iautmu.ac.ir/article-1-1368-en.html

Volume 28, Issue 1 (spring 2018) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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