1. Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit 2006;12:BR274-8.

2. Jahovic N, Cevik H, Sehirli AO, Yeğen BC, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 2003;34:282-7. [DOI:10.1034/j.1600-079X.2003.00043.x]

3. Renes IB, Verburg M, Bulsing NP, Ferdinandusse S, Büller HA, Dekker J, et al. Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation. J Pathol 2002;198:60-8. [DOI:10.1002/path.1183]

4. Oktem F, Yilmaz HR, Ozguner F, Olgar S, Ayata A, Uzare E, et al. Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester. Toxicol Ind Health 2006;22:241-7. [DOI:10.1191/0748233706th265oa]

5. Li T, Ito K, Sumi S, Fuwa T, Horie T. Protective effect of aged garlic extract (AGE) on the apoptosis of intestinal epithelial cells caused by methotrexate. Cancer Chemother Pharmacol 2009;63:873-80. [DOI:10.1007/s00280-008-0809-4]

6. Uzar E, Koyuncuoglu HR, Uz E, Yilmaz HR, Kutluhan S, Kilbas S, et al. The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Mol Cell Biochem 2006;291:63-8. [DOI:10.1007/s11010-006-9196-5]

7. Vardi N, Parlakpinar H, Ozturk F, Ates B, Gul M, Cetin A, et al. Potent protective effect of apricot and beta-carotene on methotrexate-induced intestinal oxidative damage in rats. Food Chem Toxicol 2008;46:3015-22. [DOI:10.1016/j.fct.2008.05.039]

8. Kojo S. Vitamin C: basic metabolism and its function as an index of oxidative stress. Curr Med Chem 2004;11:1041-64. [DOI:10.2174/0929867043455567]

9. Kasparová S, Brezová V, Valko M, Horecký J, Mlynárik V, Liptaj T, et al. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int 2005;46:601-11. [DOI:10.1016/j.neuint.2005.02.006]

10. Ghosh S, Ghosh D, Chattopadhyay S, Debnath J. Effect of ascorbic acid supplementation on liver and kidney toxicity in cyclophosphamide-treated female albino rats. J Toxicol Sci 1999;24:141-4. [DOI:10.2131/jts.24.3_141]

11. Gut I, Danielová V, Holubová J, Soucek P, Klucková H. Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro:effects of concentration, time and cytochrome P450-catalyzed metabolism. Arch Toxicol 2000;74:437-46. [DOI:10.1007/s002040000141]

12. Ray S, Sengupta C, Roy K. Evaluation of ascorbic acid as suppressor of cyclophosphamide induced lipid peroxidation using common laboratory markers. Act Pol Pharm 2005;62:145-52.

13. Singh S, Rana SV. Ascorbic acid improves mitochondrial function in liver of arsenic-treated rat. Toxicol Ind Health 2010;26:265-72. [DOI:10.1177/0748233710365694]

14. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40. [DOI:10.1016/j.cbi.2005.12.009]

15. Tahan G, Tarcin O, Tahan V, Eren F, Gedik N, Sahan E, et al. The effects of N-acetylcysteine on bile duct ligation-induced liver fibrosis in rats. Dig Dis Sci 2007;52:3348-54. [DOI:10.1007/s10620-006-9717-9]

16. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004;266:37-56. [DOI:10.1023/B:MCBI.0000049134.69131.89]

17. Loschen G, Flohé L, Chance B. Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria. FEBS Lett 1971;18:261-4. [DOI:10.1016/0014-5793(71)80459-3]

18. Bergmeyer HU, Hørder M, Rej R. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2). J Clin Chem Clin Biochem 1986;24:481-95.

19. Bergmeyer HU, Hørder M, Rej R. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1). J Clin Chem Clin Biochem 1986;24:497-510.