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:: Volume 29, Issue 1 (spring 2019) ::
MEDICAL SCIENCES 2019, 29(1): 18-26 Back to browse issues page
Antinociceptive effect of Salvia Sharifii Rech. F. & Esfand seed's oil in formalin test in mice
Zahra Mousavi * 1, Jinous Asgarpanah2, Farzaneh Heydarzadeh3, Ava Zenderood3, Yas Arbabi3, Rana Kharazchi3
1- Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran- Iran , mosavi50@yahoo.com
2- Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran- Iran
3- Roshangaran Girls' High School in Tehran, Iran
Abstract:   (434 Views)
Background: Salvia sharifii Rech. F. & Esfand (Lamiaceae) is an Iranian endemic plant that widely used as a medicinal plant. Due to the antinociceptive and anti-inflammatory effects of other Salvia species, the present study was conducted to investigate the antinociceptive effect of S. sharifii seed's oil (SSSO) in experimental animals.
Materials and methods: Seed's oil of S. sharifii was extracted by Soxhlet method. In order to assess the antinociceptive activity, the animals were classified to five groups: control (vehicle), S. sharifii seed's oil (20 and 100 mg/kg) and standard groups (morphine 5 mg/kg and mefenamic acid 30 mg/kg). The analgesic activities were studied by formalin test in mice. The nociceptive responses were divided to two phases; phase I (0-15minutes) and phase II (15-60 minutes). Comparisons between the groups were carried out using the analysis of variance (one way ANOVA) and post hoc Tukey's test. P<0.05 was considered as significant difference.
Results: S. sharifii seed's oil showed significant antinociceptive effects in first phase (dose 20 mg/kg) and second phase (dose 20 and 100 mg/kg) of formalin test compared to control group. These effects were comparable to morphine and mefenamic acid in chronic phase of formalin test.
Conclusion: The results indicated that S. sharifii seed's oil induced a significant antinociceptive in mice that is likely related to active constituents of this seed's oil.
Keywords: Antinociceptive, Salvia Sharifii Rech. f. & Esfand, Seed's Oil, Mice.
Full-Text [PDF 318 kb]   (178 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2018/08/25 | Accepted: 2018/10/9 | Published: 2019/03/10
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Mousavi Z, Asgarpanah J, Heydarzadeh F, Zenderood A, Arbabi Y, Kharazchi R. Antinociceptive effect of Salvia Sharifii Rech. F. & Esfand seed's oil in formalin test in mice . MEDICAL SCIENCES. 2019; 29 (1) :18-26
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Volume 29, Issue 1 (spring 2019) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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