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The effect of treadmill exercise on experimental diabetic hepatopathy in rats
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Yousef Doustar   1, Mostafa Mohammadi , Darush Mohajeri , Mehrdad Hashemi |
| 1- , vetdoustar@yahoo.com |
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Abstract: (31746 Views) |
Background: Regular exercise by increasing insulin sensitivity and improving the glucose uptake and lowering body adiposity is a powerful non-pharmacological tool for prevention and treatment of diabetes mellitus. Diabetic hepatopathy is the main cause of liver failure. The purpose of this study was to evaluate the effect of regular exercise on diabetic hepatopathy.
Materials and methods: In this experimental study, 56 wistar male rats with approximate age of 12 weeks and 200-300g weight were allocated into two equal groups of treatment and control. For induction of diabetes, these two groups were injected by streptozotocin (50 mg/kg) intraperitoneally. The treatment group was kept in normal conditions of management with regular exercise (treadmill) as 5 days a week, an hour every day, for 12 weeks. In control group, subjects have normal conditions without any physical activity and regular exercise. After 12 weeks, liver tissues were sampled in both groups and 5-6 micron tissue sections were prepared through H&E staining method.
Results: Histopathological study in control group showed hepatosclerosis, central vein perivascular cuffing of mononuclear inflammatory cells, hepatocellular degeneration, sclerosing hyaline necrosis, apoptosis, dense perisinusoidal, and periportal and perivenular fibrosis. Mild pathological changes were observed in treatment group and significant differences were observed between two groups.
Conclusion: Treadmill exercise is capable in reduction of pathological changes and improves diabetic hepatopathy to near normal histology. |
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| Keywords: Diabetic Hepatopathy, Treadmill exercise, Diabetes Mellitus |
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Full-Text [PDF 1132 kb]
(4834 Downloads)
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Subject:
Epidemiology
Received: 2006/09/6 | Published: 2009/04/15
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