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:: Volume 19, Issue 1 (Spring 2009) ::
MEDICAL SCIENCES 2009, 19(1): 49-53 Back to browse issues page
Plasma free 8-iso-PGF2α levels in normotensive and preeclamptic pregnancies
Farinaz Seifi 1, Abolfazl Mehdizadeh , Isa Nourmohammadi
1- , f_seifi@yahoo.com
Abstract:   (27310 Views)
Background: Preeclampsia is a main cause of morbidity and mortality of pregnant women worldwide. Recently oxidative stress was considered as a part of pathophysiolgy of preeclamsia and 8-iso-prostaglandin F2α (8-iso-PGF2α) is known as a marker of oxidative stress. The purpose of this study was to measure and compare plasma concentration of free 8-iso-PG F2α in women with normotensive and preeclamptic pregnancies.
Materials and methods: In this descriptive-analytic study, Plasma free 8-iso-PGF2α levels were measured in pregnant women with preeclamsia (n=42) and normotensive pregnant women (n=39) between 28-38 weeks of gestation. Women in two groups were matched in age, gestational age and socioeconomic statue and all women were nulligravid.
Results: Free 8-iso-PGF2α levels were not significantly different in women with preeclamsia and normotensive group (17808 vs. 24288 pg/dl, NS). Plasma free 8-iso-PGF2α levels were increased in severe compared to mild preeclampsia (NS). Neonates weight of preeclamptic mothers was significantly lower than neonates of normotensive women (p<0.0001).
Conclusion: Although free 8-iso-PGF2α is a marker of oxidative stress in vitro, but its measurement is not valuable in clinical medicine. However, further studies in normal pregnancy and preeclampsia will be needed.
Keywords: Free 8-iso-PGF2α, Pregnancy, Preeclampsia
Full-Text [PDF 206 kb]   (2994 Downloads)    
Subject: Epidemiology
Received: 2006/09/6 | Published: 2009/04/15
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Seifi F, Mehdizadeh A, Nourmohammadi I. Plasma free 8-iso-PGF2α levels in normotensive and preeclamptic pregnancies. MEDICAL SCIENCES 2009; 19 (1) :49-53
URL: http://tmuj.iautmu.ac.ir/article-1-186-en.html


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Volume 19, Issue 1 (Spring 2009) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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