Background: Preeclampsia is a main cause of morbidity and mortality of pregnant women worldwide. Recently oxidative stress was considered as a part of pathophysiolgy of preeclamsia and 8-iso-prostaglandin F2α (8-iso-PGF2α) is known as a marker of oxidative stress. The purpose of this study was to measure and compare plasma concentration of free 8-iso-PG F2α in women with normotensive and preeclamptic pregnancies.
Materials and methods: In this descriptive-analytic study, Plasma free 8-iso-PGF2α levels were measured in pregnant women with preeclamsia (n=42) and normotensive pregnant women (n=39) between 28-38 weeks of gestation. Women in two groups were matched in age, gestational age and socioeconomic statue and all women were nulligravid.
Results: Free 8-iso-PGF2α levels were not significantly different in women with preeclamsia and normotensive group (17808 vs. 24288 pg/dl, NS). Plasma free 8-iso-PGF2α levels were increased in severe compared to mild preeclampsia (NS). Neonates weight of preeclamptic mothers was significantly lower than neonates of normotensive women (p<0.0001).
Conclusion: Although free 8-iso-PGF2α is a marker of oxidative stress in vitro, but its measurement is not valuable in clinical medicine. However, further studies in normal pregnancy and preeclampsia will be needed.
Seifi F, Mehdizadeh A, Nourmohammadi I. Plasma free 8-iso-PGF2α levels in normotensive and preeclamptic pregnancies. MEDICAL SCIENCES 2009; 19 (1) :49-53 URL: http://tmuj.iautmu.ac.ir/article-1-186-en.html