:: Volume 32, Issue 4 (winter 2022) ::
MEDICAL SCIENCES 2022, 32(4): 379-388 Back to browse issues page
The effect of gallic acid on oxidative stress parameters and hippocampal cell density in ischemia-renal reperfusion model
Hossein Roshanfekr1 , Mohammad Amin Edalatmanesh 2, Heydar Aghababa3
1- PhD Candidate in Animal Physiology, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- , amin.edalatmanesh@gmail.com
3- of Physiology, Department of Biology, College of Sciences, Arsanjan Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (802 Views)
Background: Although acute renal injury (AKI) is a consequence of renal ischemia-reperfusion (RIR), RIR-induced oxidative damage also affects distant organs. The aim of this study was to evaluate the effect of gallic acid (GA) on oxidative stress parameters and neuronal density in the brain hippocampus following RIR.
Materials and methods: 48 male Wistar rats were randomly divided into 4 groups, including control, ischemia/reperfusion+normal saline (RIR+Saline), and ischemia/reperfusion+GA groups at doses of 100 mg/kg (RIR+GA100) and 200 mg/kg (RIR+GA200). Animals in all groups except control underwent unilateral nephrectomy (right). The treatments were performed for 14 days and then, the left kidney was ischemized for 45 minutes. After 72 hours, hippocampal activity levels of catalase (CAT), glutathione peroxidase (GPx), total antioxidant capacity (TAC) and malondialdehyde (MDA) were evaluated. Finally, neuronal density was measured in CA1 and CA3 regions of the hippocampus.
Results: A significant decrease in CAT, GPx and TAC and an increase in MDA was observed in RIR + Saline group compared to the control group, which was associated with a significant decrease in neuronal density in CA1/CA3 (p<0.05). While in the GA-treated groups, along with a significant increase in CAT, GPx and TAC and a decrease in MDA in the hippocampus, showed a significant increase in neuronal density of CA1/CA3 regions compared to the RIR+Saline group (p˂0.05).
Conclusion: GA pretreatment can ameliorate oxidative damage and neuronal death in the brain hippocampus of rats with RIR-induced acute renal damage.
 
Keywords: Gallic acid, Hippocampus, Acute renal failure, Rat
Full-Text [PDF 361 kb]   (316 Downloads)    
Semi-pilot: Experimental | Subject: Animal Biology
Received: 2022/05/22 | Accepted: 2022/08/16 | Published: 2022/12/31
References
1. Lu R, Kiernan MC, Murray A, Rosner MH, Ronco C. Kidney-brain crosstalk in the acute and chronic setting. Nat Rev Nephrol 2015;11:707-19. 2. Oh DJ. A long journey for acute kidney injury biomarkers. Ren Fail 2020;42:154-165. https://doi.org/10.1080/0886022X.2020.1721300 3. Gong L, He J, Sun X, Li L, Zhang X, Gan H. Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury. Biomed Pharmacother 2020;125:110021. https://doi.org/10.1016/j.biopha.2020.110021 4. Abd El-Kader M, Taha RI. Comparative nephroprotective effects of curcumin and etoricoxib against cisplatin-induced acute kidney injury in rats. Acta Histochem 2020;122:151534. https://doi.org/10.1016/j.acthis.2020.151534 5. Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, et al. Global prevalence of chronic kidney disease-a systematic review and meta-analysis. PloS One 2016;11: e0158765. https://doi.org/10.1371/journal.pone.0158765 6. Sepanlou SG, Barahimi H, Najafi I, Kamangar F, Poustchi H, Shakeri R, et al. Prevalence and determinants of chronic kidney disease in northeast of Iran: Results of the Golestan cohort study. PloS One 2017;12: e0176540. https://doi.org/10.1371/journal.pone.0176540 7. Shang Y, Madduma Hewage S, Wijerathne CUB, Siow YL, Isaak CK, O K. Kidney Ischemia-Reperfusion Elicits Acute Liver Injury and Inflammatory Response. Front Med (Lausanne) 2020;7:201. https://doi.org/10.3389/fmed.2020.00201 8. Azarkish F, Armin F, Parvar AAA, Dehghani A. The influence of renal ischemia-reperfusion injury on remote organs: The histological brain changes in male and female rats. Brain Circ 2021;7:194-200. https://doi.org/10.4103/bc.bc_3_21 9. Lu R, Kiernan MC, Murray A, Rosner MH, Ronco C. Kidney-brain crosstalk in the acute and chronic setting. Nat Rev Nephrol 2015;11:707-19. 10. López-Andrés N, Jaisser F, Barrera-Chimal J. Editorial: Kidney and Distant Organ Crosstalk in Health and Disease. Front Physiol 2021;12:712535. https://doi.org/10.3389/fphys.2021.712535 11. Vafapour M, Nematbakhsh M, Monajemi R, Mazaheri S, Talebi A, Talebi N, et al. Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference. Adv Biomed Res 2015;4:158. https://doi.org/10.4103/2277-9175.161585 12. Gholamine B, Houshmand G, Hosseinzadeh A, Kalantar M, Mehrzadi S, Goudarzi M. Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats. Drug Chem Toxicol 2021;44:341-352. https://doi.org/10.1080/01480545.2019.1591434 13. Dludla PV, Nkambule BB, Jack B, Mkandla Z, Mutize T, Silvestri S, et al. Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid. Nutrients 2018;11:23. https://doi.org/10.3390/nu11010023 14. Kahkeshani N, Farzaei F, Fotouhi M, Alavi SS, Bahramsoltani R, Naseri R, et al. Pharmacological effects of gallic acid in health and diseases: A mechanistic review. Iran J Basic Med Sci 2019;22:225-237. 15. Canbek M, Bayramoglu G, Senturk H, Oztopcu Vatan AP, Uyanoglu M, et al. The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment. Bratisl Lek Listy 2014;115:557-62. https://doi.org/10.4149/BLL_2014_108 16. Singh JP, Singh AP, Bhatti R. Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. J Surg Res 2014;187:631-9 https://doi.org/10.1016/j.jss.2013.11.1088 17. Eslamifar Z, Moridnia A, Sabbagh S, Ghaffaripour R, Jafaripour L, Behzadifard M. Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression. Biomed Res Int 2021;2021:2195238. https://doi.org/10.1155/2021/2195238 18. Soliman E, Shewaikh SM, Fahmy A, Elshazly S. Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats. Int Urol Nephrol 2021;53:1713-1721 https://doi.org/10.1007/s11255-021-02827-5 19. Li J, Hong Z, Liu H, Zhou J, Cui L, Yuan S, et al. Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation. Front Pharmacol 2016;7:106. https://doi.org/10.3389/fphar.2016.00106 20. Edalatmanesh MA, Nemati S, Khodabandeh H. Systemic Transplantation Effect of Human Adipose Tissue Derived Mesenchymal Stem Cells on Cognitive Deficits and Hippocampal Antioxidant Capacity in Trimethyltin Model of Alzheimer's Disease. SJIUM 2022; 29: 32-43. https://doi.org/10.52547/sjimu.29.5.32 21. Abutalebi Ardakani Z, Edalatmanesh MA. The effect of coenzyme-Q10 on neuroinflammation and hippocampal cell damage in a model of monosodium glutamate induced excitotoxicity. Jahrom Medical Journal 2021;19:45-54. 22. Wijerathne CUB, Madduma Hewage S, Siow YL, O K. Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart. Biomolecules 2020;10:1565. https://doi.org/10.3390/biom10111565 23. Tanaka S, Okusa MD. Crosstalk between the nervous system and the kidney. Kidney Int 2020;97:466-476. https://doi.org/10.1016/j.kint.2019.10.032 24. Miglinas M, Cesniene U, Janusaite MM, Vinikovas A. Cerebrovascular Disease and Cognition in Chronic Kidney Disease Patients. Front Cardiovasc Med 2020;7:96. https://doi.org/10.3389/fcvm.2020.00096 25. Wu VC, Wu PC, Wu CH, Huang TM, Chang CH, Tsai PR, et al. The impact of acute kidney injury on the long-term risk of stroke. J Am Heart Assoc 2014;3:e000933. https://doi.org/10.1161/JAHA.114.000933 26. Malek M. Brain consequences of acute kidney injury: Focusing on the hippocampus. Kidney Res Clin Pract 2018;37:315-322. https://doi.org/10.23876/j.krcp.18.0056 27. Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, et al. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol 2008;19:1360-70. https://doi.org/10.1681/ASN.2007080901 28. Yang HY, Lee TH. Antioxidant enzymes as redox-based biomarkers: a brief review. BMB Rep 2015;48:200-8. https://doi.org/10.5483/BMBRep.2015.48.4.274 29. Bartsch T, Döhring J, Reuter S, Finke C, Rohr A, Brauer H, et al. Selective neuronal vulnerability of human hippocampal CA1 neurons: lesion evolution, temporal course, and pattern of hippocampal damage in diffusion-weighted MR imaging. J Cereb Blood Flow Metab 2015;35:1836-45. https://doi.org/10.1038/jcbfm.2015.137 30. Tahamtan M, Kohlmeier KA, Faatehi M, Basiri M, Shabani M. Electrophysiological and inflammatory changes of CA1 area in male rats exposed to acute kidney injury: Neuroprotective effects of erythropoietin. Brain Res Bull 2021;171:25-34. https://doi.org/10.1016/j.brainresbull.2021.03.007 31. Akomolafe SF, Akinyemi AJ, Anadozie SO. Phenolic Acids (Gallic and Tannic Acids) Modulate Antioxidant Status and Cisplatin Induced Nephrotoxicity in Rats. Int Sch Res Notices 2014;2014:984709. https://doi.org/10.1155/2014/984709 32. Sarkaki AR, Hoseinynejad Kh, Khombi Shooshtari M, Rashno M. Synaptic plasticity and cognitive impairment consequences to acute kidney injury: Protective role of ellagic acid. Iran J Basic Med Sci 2022; 25:621-628. 33. Ahmadvand H, Yalameha B, Adibhesami G, Nasri M, Naderi N, Babaeenezhad E, et al. The Protective Role of Gallic Acid Pretreatment On Renal Ischemia-reperfusion Injury in Rats. Rep Biochem Mol Biol 2019;8:42-48. [DOI:10.1038/nrneph.2015.131]

XML   Persian Abstract   Print

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 32, Issue 4 (winter 2022) Back to browse issues page