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The relationship between serum selenium levels and chronic inflammation and malnutrition in patients with advanced renal failure in dialysis wards of Bu-Ali and Farhikhtegan Hospitals
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Yekta Aminian1    , Farahnaz Pasha2 , Mehdi Afkar3 |
1- Internal Medicine Resident, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Assistant Professor, Department of Nephrology, Farhikhtegan Hospital, Faculty of Medicine, Islamic Azad University, Tehran, Iran , farahnazpasha@gmail.com
3- Assistant Professor, Department of Community Medicine, Faculty of Medicine, Islamic Azad University, Tehran, Iran |
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Abstract: (25 Views) |
Background: Selenium (Se) is an essential trace element with antioxidant properties, playing a key role in mitigating oxidative stress and inflammation This study aimed to evaluate the relationship between serum selenium levels and inflammatory markers in patients with end-stage renal disease (ESRD) undergoing hemodialysis.
Materials and methods: This cross-sectional study included 72 patients with ESRD undergoing chronic hemodialysis at Bu-Ali and Farhikhtegan Hospitals in 2022-2023. Data were collected using convenience sampling. Serum selenium, albumin, ESR, CRP, ferritin, BMI, and triglycerides were measured through laboratory testing. Demographic data such as age, gender, and were recorded. Statistical analysis was conducted using SPSS version 26, by ANOVA to examine the relationship between mentioned factors.
Results: The study population comprised 38.9% women and 61.1% men, with a mean age of 61.19 years. The mean serum selenium level was 86.56 ± 36.76 μg/L. No significant relationship was found between selenium levels with ESR and ferritin (P>0.05). However, there was a significant inverse relationship between selenium and CRP levels (P<0.05), indicating that lower selenium levels were associated with higher CRP levels. No significant relationship was observed between selenium levels and BMI, albumin, and triglycerides (P>0.05).
Conclusion: Among the inflammatory and nutritional variables, selenium deficiency in hemodialysis patients is only associated with increased CRP levels, which indicates the association between selenium levels and this factor. The inverse relationship between selenium and CRP suggests that maintaining adequate selenium levels may be an important component of comprehensive inflammation management strategies in hemodialysis patients.
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| Keywords: Selenium, Inflammatory markers, Malnutrition |
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Full-Text [PDF 743 kb]
(7 Downloads)
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Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Nephrology
Received: 2025/07/7 | Accepted: 2025/10/19 | Published: 2026/07/1
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