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:: Volume 14, Issue 2 (winter 2004) ::
MEDICAL SCIENCES 2004, 14(2): 93-97 Back to browse issues page
Clinical course of myelodysplastic syndrome
Sedighi Sanambar *1, Monadizadeh Davoud
Abstract:   (20183 Views)
Background: Myelodysplastic syndrome (MDS) is a group of neoplastic disorder of hematopoietic stem cells characterized by ineffective hematopoiesis. This study was performed to evaluate the clinical course of MDS and determine factors influencing survival in agroup of Iranian patients.
Material and methods: During this descriptive-analytical study, clinical manifestations, pathologic and cytogenetic findings of 80 patients with MDS referring during a 16-year period to Modarres and Mehrdad hospitals in Tehran were reviewed.
Results: The mean age (± standard deviation) was 57.6±17.6 years (13-85 years). The M/F ratio was 1.6/1. The frequency of the FAB subtypes were: refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS) 54%, refractory anemia with excess blasts (RAEB) 19%, chronic myelomonocytic leukemia (CMML) 15/5%, refractory anemia with excess blasts in transformation (RAEBT) 11/5%. Anemia was by far the most common symptom (78%). Kaplan-Meier analysis revealed a median survival of 14.6 months and a mean of 21 months. Leukemia occurred in 64% of females and 35.8% of males. The major variables predictive of survival were age, sex, WBC count, LDH, subtype, and the percentage of blasts in peripheral blood smear and bone marrow, however, COX regression revealed the percentage of blasts in the bone marrow as the only independent variable for determining survival (P=0.002).
Conclusion: Comparing our data with several other studies one could note that the age of our patients with MDS is lower than western population. Leukemia is more frequent among females and the major prognostic features lie in the percentage of blasts in the bone marrow.
Keywords: Myelodysplastic syndrome, Prognosis.
Full-Text [PDF 247 kb]   (5848 Downloads)    
Subject: Nutrition Sciences
Received: 2006/09/6
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Sedighi Sanambar, Monadizadeh Davoud. Clinical course of myelodysplastic syndrome. MEDICAL SCIENCES. 2004; 14 (2) :93-97
URL: http://tmuj.iautmu.ac.ir/article-1-251-en.html


Volume 14, Issue 2 (winter 2004) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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