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Effect of Salvia officinalis hydroalcoholic extract on liver enzymes in male rat
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Maryam Khosravi1   , Shahrzad Khakpour2 , Golnaz Tajadod3 , Fatemeh Tokazabani Balasi4 |
1- Department of Biology, Faculty of Biologic Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran Department of Biology, Faculty of Biologic Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
2- Department of Physiology, Medical Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , shahrzad_khakpour@yahoo.com
3- Department of Biology, Faculty of Biologic Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
4- MSc Student, Department of Physiology, Faculty of Biologic Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran |
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Abstract: (14619 Views) |
Background: Oxidative stress induces different diseases, such as diabetes, cancer, arteriosclerosis and Alzheimer. In this study, the antioxidant effect of hydroalcoholic extract of Salvia officinalis was investigated.
Materials and Methods: In this experimental study, isoniazid, as an anti tuberculosis agent, has been used to induce free radicals. Male rats were used and divided in 9 groups in each group, 7 rats were included. Isoniazid with dose of 50 mg/kg was orally administered to rats continuously once per day for 28 days using a feeding atraumatic needle. The treated groups received hydroalcoholic extract of Salvia officinalis with the doses of 100, 250 and 400 mg/kg intraperitonally, and the effects of the extract and isoniazid on liver enzymes such as aspartate aminotransferase (AST), alanin aminotransferase (ALT), alkaline phosphatase (ALP) and gama glutamyl transferase (GGT) were studied.
Results: Serum levels of AST, ALT, ALP and GGT and also hepatic histopathologic observations indicated that the effective doses of Salvia officinalis extract were 100 and 250 mg/kg.
Conclusion: This study showed that Salvia officinalis hydroalcoholic extract is potentially effective in the reduction of damages caused by oxidative stress. |
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| Keywords: Free radical, Salvia officinalis, Oxidative stress, Liver enzymes, Isoniazid, Rat. |
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Full-Text [PDF 763 kb]
(7056 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2013/06/19 | Published: 2013/06/15
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