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Association between human Papillomavirus (HPV) and breast cancer in Iranian patients
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Zahra Tahmasebi Fard   1, Afshin Abdirad2 , Minoo Saatian3 , Leyla Arefian4 |
1- Young Researchers Club Islamic Azad University, Roudehen Branch, Roudehen, Iran , Ztahmasebi@riau.ac.ir
2- Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Pathology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4- Pathologist, Anatomical Clinical Pathologist, Aban General Hospital. Tehran, Iran |
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Abstract: (11541 Views) |
Background: Viruses, such as human Papillomavirus (HPV), have been detected in benign breast tissues and breast tumors and are considered to be involved in the etiology of breast cancer, but there are controversial data on the meaning of viral induction of breast cancer. The aim of this study was to investigate the presence of human Papillomavirus (HPV) in Iranian patients with breast carcinoma.
Materials and Methods: In this case- control study, paraffin-embedded sections from 64 female patients with breast carcinoma and 53 breast tissues from patients with fibrocystic disease, as control, were analyzed for presence of HPV DNA. Real-Time PCR was used to amplify consensus GP5+/GP6+ HPV sequences.
Results: HPV DNA sequences were detected in 3 of the 53 benign breast tissue samples, but none of the breast carcinoma samples was identified.
Conclusion: Our analysis could not confirm a role of HPV in breast cancer. |
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| Keywords: Human Papillomavirus (HPV), Breast cancer, Real-Time PCR |
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Full-Text [PDF 393 kb]
(6926 Downloads)
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Semi-pilot: case-control |
Subject:
Pathology
Received: 2013/06/19 | Published: 2013/06/15
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