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:: Volume 23, Issue 3 (fall 2013) ::
MEDICAL SCIENCES 2013, 23(3): 174-178 Back to browse issues page
Effect of quinine on latency and amplitude of visual evoked potential P100 peak in male mice
Nasrin Torabi1, Seyed Mohammad Masoud Shushtarian *2, Ramesh Monajemi3
1- Student of Animal Physiology, Department of Biology, Islamic Azad University, Falavarjan Branch, Esfahan, Iran
2- Department of Biophysics and Medical Physics, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , nts320@yahoo.com
3- Department of Biology, Islamic Azad University, Falavarjan Branch, Esfahan, Iran
Abstract:   (7964 Views)
Background: Quinine is used for treatment of many disorders, such as malaria and rheumatoid arthritis. Besides good therapeutic effects, it may have multiple adverse effects. In this study, the effects of quinine on latency and amplitude in visual evoked potential (VEP) were evaluated.
Materials and Methods: In this experimental study, 50 male Syrian mice were used as control. Five groups of ten mice received doses of 2.5, 12.5, 25, 50, and 62.5 mg of quinine and one group of ten mice was given 70 mg acetone extract of Cinchona plant intraperitoneally for 14 days. The latency and amplitude of different groups in VEP were recorded.
Results: The latency was significantly increased, as parallel as dosage, in 14 days (P<0.05), while the amplitude was significantly decreased, as parallel as dosage, in 14 days (P<0.05).
Conclusion: Quinine resulted in significant increase of latency and decrease of amplitude and leaded to visual loss, possibly due to deposition of quinine on nerve fibers and cone-shaped and cylindrical cells leading to increase in latency phase of transmission from retina to fovea.
Keywords: Quinine, Adverse effects, Visual evoked potential
Full-Text [PDF 144 kb]   (1281 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2013/09/22
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Torabi N, Shushtarian S M M, Monajemi R. Effect of quinine on latency and amplitude of visual evoked potential P100 peak in male mice. MEDICAL SCIENCES. 2013; 23 (3) :174-178
URL: http://tmuj.iautmu.ac.ir/article-1-702-en.html


Volume 23, Issue 3 (fall 2013) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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