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:: Volume 23, Issue 3 (fall 2013) ::
MEDICAL SCIENCES 2013, 23(3): 206-211 Back to browse issues page
Anti bacterial scaffolds based on gum tragacanth for wound caring under moist conditions
Ramin Khajavi *1, Maryam Hajmaleki2, Farhad Shahmirzaei Ashtiyani3, Tayebeh Toliat4, Morteza Sattari5, Mohammad Mirjalili
1- Department of Textile Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran , khajavi@azad.ac.ir
2- MSc of Textile Engineering, Textile Chemistry and Fiber Sciences, Islamic Azad University, Science and Research Campus, Tehran, Iran
3- MSc of Textile Engineering, Textile Chemistry and Fiber Sciences, Islamic Azad University, Yazd Branch, Yazd, Iran
4- Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Bacteriology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
Abstract:   (22775 Views)
Background: When hydrocolloids dressings are loaded with an antibacterial agent, they can also prevent infection during wound cicatrisation. To consider interesting properties of traditional Gum Tragacanth such as moisture absorption, hydrocolloid formation, drug holding and releasing abilities, it was aimed to introduce a scaffold wound dress based on Gum Tragacanth with drug release ability simultaneously.
Materials and Methods: In this experimental study, gum tragacanth from Astragalus gossypinus species (Iranian species) is solved and loaded with an aminoglycoside antibiotic (Gentamicin). Prepared solution transformed to a nano fibers network “scaffold” by lyophilization method. Samples were characterized by scanning electron microscopy, fourier transform infrared and X-ray diffraction methods and their antimicrobial and moisture holding properties were determined.
Results: Gum tragacanth showed a proper potential for dispersing gentamicin and the drug was loaded into polymer matrix without any aggregation. Loaded gum tragacanth with gentamicin is successfully transformed to a nanofibers scaffold by lyophilization. The diameters of fibers were in the range of 300nm to 2µm. Transformed gum tragacanth into scaffolds showed declined regain content (up to 50%) due to the ordering and orientation of polymer chains. Ordered hydroxyl groups also observed in FTIR graphs. Regarding the zones of inhibition, scaffolds also showed acceptable antibacterial activities.
Conclusion: Produced scaffolds are capable of absorbing wound’s exocrine liquid easily due to their high specific area of nanofibers. When it is turned to gel by moisture sorption, the release of loaded Gentamicin would be enhanced.
Keywords: Gum tragacanth, Moist wound dressing, Scaffold, Gentamicin, Lyophilization
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Semi-pilot: Experimental | Subject: Chemistry
Received: 2013/09/22
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Khajavi R, Hajmaleki M, Shahmirzaei Ashtiyani F, Toliat T, Sattari M, Mirjalili M. Anti bacterial scaffolds based on gum tragacanth for wound caring under moist conditions. MEDICAL SCIENCES. 2013; 23 (3) :206-211
URL: http://tmuj.iautmu.ac.ir/article-1-708-en.html


Volume 23, Issue 3 (fall 2013) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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