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Evaluation of effects of phenol levels on testicular histopathology and morphometric parameters of some organs in Wistar rats
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Maryam Modhej1   , Saleh Tabatabaei2 , Mohsen Sari2 , Somayeh Sallary2 , Esrafil Mansouri3 |
1- Animal Physiology, Department of Animal Sciences, Ramin Agriculture and Natural Resources University, Khuzestan, Iran , modhej.2012@yahoo.com
2- Department of Animal Sciences, Ramin Agriculture and Natural Resources University, Khuzestan, Iran
3- Anatomy Ward, Faculty of Medicine, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran |
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Abstract: (8705 Views) |
Background: Organic solvents, such as phenol, are widely used in different industries and occupations. The aim of this study was to evaluate the effects of phenol on testicular morphology and morphometry and also some digestive organs and body weight.
Materials and methods: In this experimental study, 54 male wistar rats were placed in 3 groups, including control and phenol recipient of 100 and 200 mg/kg/bw. Rats received phenol solution or water by gavage every day for 15 days. At the end of study, 3 rats from each group were weighted. After anesthetize of rats, right testes dimensions, weight and histological structure as well as weights of some digestive organs were determined.
Results: Phenol at 100 and 200 mg/kg.bw significantly increased the spermatogonia cell count and lumen seminiferus tubule diameter, compared with the control group (p<0.05). While, 200 mg/kg/bw phenol reduced the epithelial thickness in compared with control group (p<0.05). Testicular morphometry was not affected by phenol treatments (p>0.05). Stomach and colon weights in phenol receiving groups were significantly lower than the control group (p<0.05).
Conclusion: The results indicate the effectiveness of phenol on testes morphological structure and gastrointestinal tract organs weight.
Keywords: Histopathology, Morphometry, Gastrointestinal tract, Testes, Rat, Phenol. |
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| Keywords: Histopathology, Morphometry, Gastrointestinal tract, Testes, Rat, Phenol. |
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Full-Text [PDF 764 kb]
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2014/03/9 | Accepted: 2014/03/9 | Published: 2014/03/9
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Modhej M, Tabatabaei S, Sari M, Sallary S, Mansouri E. Evaluation of effects of phenol levels on testicular histopathology and morphometric parameters of some organs in Wistar rats. MEDICAL SCIENCES 2014; 24 (1) :8-13 URL: http://tmuj.iautmu.ac.ir/article-1-765-en.html
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