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:: Volume 25, Issue 2 (summer 2015) ::
MEDICAL SCIENCES 2015, 25(2): 105-111 Back to browse issues page
Hepatoprotective effect of hydro-alcoholic extract of Oliveria decumbens against hepatotoxicity induced by cadmium chloride in adult male rat
Somayeh Rahimi Kazerouni1 , Mokhtar Mokhtari 2, Mehrdad Shariati3 , Maryam Rahimi Kazerooni1
1- in Animal Sciences, Department of Biology, Islamic Azad University, Kazeroun Branch, Kazeroun, Iran
2- of Physiology, Department of Biology, Islamic Azad University, Kazeroun Branch, Kazeroun, Iran , Mokhtar_Mokhtary@Yahoo.Com
3- PhD of Evolutionary Biology, Department of Biology, Islamic Azad University, Kazeroun Branch, Kazeroun, Iran
Abstract:   (8803 Views)
Background: Cadmium is a toxic metal with wide usage in industry. It exerts toxic effects on various organs, including liver. In this study, the hepato-protective effect of hydro alcoholic extract of Oliveria decumbens on AST, ALT, ALP Enzymes following toxicity induced by cadmium chloride was investigated in male rat.
 Materials and methods: In this experimental study, 48 adult male Wistar rats were divided into 6 groups of 8. These groups were as follow: the control, left untreated the sham, just received distilled water the experimental group 1, treated with 2mg/kg cadmium chloride the experimental group 2 received 500 mg/kg oliveria extract, and experimental groups 3 and 4 initially received 2mg/kg cadmium chloride followed by 250 and 500 mg/kg extract respectively for 21 days. At the end of experiment, blood samples were taken, and were prepared for measuring serum levels of hepatic enzymes.
 Results: In comparison with control and sham groups, serum levels of ALT, AST, ALP enzymes increased significantly in the experimental group 1. There were no significant changes in the enzyme levels in the experimental group 2. There were no significant changes in the levels of ALT, AST, ALP enzymes in the experimental group 3 compared to control and sham groups. A significant decrease was observed in the levels of ALT, AST, ALP enzymes in the experimental group 4 in comparison with experimental group 1 (P<0.05).
 Conclusion: The results showed that O.decumbens extract could possess protective effect against hepatotoxicity induced by heavy metals, such as cadmium and could improve the liver function.
 Keywords: ALT, AST, ALP, Cadmium chloride, Oliveria decumbens, Rat.
Keywords: ALT, AST, ALP, Cadmium chloride, Oliveria decumbens, Rat
Full-Text [PDF 144 kb]   (4040 Downloads)    
Semi-pilot: Experimental | Subject: Animal Biology
Received: 2015/06/16 | Accepted: 2015/06/16 | Published: 2015/06/16
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Rahimi Kazerouni S, Mokhtari M, Shariati M, Rahimi Kazerooni M. Hepatoprotective effect of hydro-alcoholic extract of Oliveria decumbens against hepatotoxicity induced by cadmium chloride in adult male rat . MEDICAL SCIENCES 2015; 25 (2) :105-111
URL: http://tmuj.iautmu.ac.ir/article-1-938-en.html


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Volume 25, Issue 2 (summer 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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