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Background: Multiple sclerosis (MS), which is associated with the destruction of the myelin of the nerve cells, causes many motor-sensory problems and disrupts their quality of life. One of the remedies for this disease is glatiramer, which is injected daily as a peptide at a dose of 20 mg, tolerating of it for a long period of time is too difficult due to irritation of injection site. In this study with using nanotechnology tried to control the release rate of the drug to increase the interval of injections and consequently, patient’s tolerance.
Materials and methods: Glatiramer solid lipid nanoparticles (SLNs) were prepared using cholesterol as carrier by high shear homogenization technique. The particle size and zeta potential were investigated. The particle morphology was evaluated by SEM (Scanning Electron Microscopy) and finally the drug loading efficacy and drug release pattern were studied. To enhance the stability of the prepared nanoparticles, lyophilization was carried out by mannitol as cryoprotectant agent.
Results: The results showed that particles prepared with a size less than 300 nm and PDI: Polydispersity Index of less than 0.5, drug loading rate of over 74% and release over 6 days could be a good candidate for replacement of current treatment with this drug.
Conclusion: It seems that drug delivery of glatiramer with nanotechnology could provide a new solution for the problem of controlling MS with this drug in the future with more patient compliance.