RT - Journal Article T1 - Evaluation of serum levels of antioxidant trace elements, zinc, copper, selenium and manganese, in children with acute lymphoblastic leukemia before treatment JF - iau-tmuj YR - 2019 JO - iau-tmuj VO - 29 IS - 1 UR - http://tmuj.iautmu.ac.ir/article-1-1530-en.html SP - 48 EP - 55 K1 - Antioxidant trace elements K1 - Acute lymphoblastic leukemia. AB - Background: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Antioxidants participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of antioxidant elements, including Zn, Cu, Se and Mn, in serum of children with acute lymphoblastic leukemia before treatment. Materials and methods: In this study, 20 children just diagnosed ALL before chemotherapy (mean age, 6.6±4.6) compared to 20 healthy controls (mean age, 10.3±2.7). Concentration of the elements were measured with atomic absorption spectroscopy Results: serum levels of Mn were significantly lower in acute leukemia than in controls (P=0.03), while Cu was significantly elevated (P <0.0001). There were no significant difference regarding Zn and Se between two groups (P =0.07 and P =0.35, respectively). Conclusion: Based on obtained results, changes of serum level of these antioxidants could likely have biological role in initiation or progression of leukemia. Further studies are needed to clarify the role of these factors in pathogenesis of acute leukemia LA eng UL http://tmuj.iautmu.ac.ir/article-1-1530-en.html M3 10.29252/iau.29.1.48 ER -