@ARTICLE{Mohebbi, author = {Milanizadeh, Saman and Mohammad Alizadeh, Amir Houshang and Azimzadeh, Pedram and Romani, Sara and Roshani, Mohammad and Khan Yaghma, Mahsa and Mohebbi, Seyed Reza and Zali, Mohammad Reza and }, title = {Association of D19H polymorphism of ABCG8 gene with gallstone susceptibility}, volume = {23}, number = {3}, abstract ={Background: Increased level of cholesterol may be saturated in the gall bladder resulting in gall stone. Product of ABCG8 gene is responsible for evacuation of cholesterol from cells and made dissolved cholesterol in bile. It appears that genetic changes of this gene can alter its function and make gall stone. This study was designed to evaluate association of D19H polymorphism of ABCG8 gene with gallstone susceptibility. Materials and Methods: This was a case-control research that was conducted on 100 gallstone patients and 106 healthy controls without any family history of gallstone. For DNA extraction, salting out method has been used and for detection of alleles in polymorphic region, PCR-RFLP has been used. Results: heterozygote genotype in this polymorphic region (G/C) had association with gallstone formation (OR=7.14 95%CI=3.47-14.66 P }, URL = {http://tmuj.iautmu.ac.ir/article-1-704-en.html}, eprint = {http://tmuj.iautmu.ac.ir/article-1-704-en.pdf}, journal = {Medical Sciences Journal of Islamic Azad University}, doi = {}, year = {2013} }