Medical Sciences Journal of Islamic Azad University
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران
MEDICAL SCIENCES
Medical Sciences
http://tmuj.iautmu.ac.ir
1
admin
1023-5922
2008-3386
000
10.61882/iau
000
1023-5922
000
fa
jalali
1401
12
1
gregorian
2023
3
1
33
1
online
1
fulltext
fa
ارزیابی سمیت خوراکی شربت ذرت با فروکتوز بالا-55 ( HFCS-55 ): یک مطالعه 28 روزه برروی تخمدان ورحم موش صحرایی ماده
Toxicity assessment of high fructose corn syrup-55: a repeated dose oral toxicity study in uterus and ovaries of female rats
داروسازي
Pharmacology
تجربي
Experimental
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">سابقه و هدف</span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:Nazanin"><span style="font-weight:normal">:</span></span></span></i> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">شربت</span></span></span></i><i> </i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">ذ</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">رت با فروکتوز بالا-55 (55-</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS</span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">)، شیرین کننده متداولی در صنایع غذایی است.</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">اخیرا اثرات سوء مصرف خوراکی بلند مدت کنترل نشده 55-</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS</span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">در مقایسه</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">با سوکروز بر ناکارآمدی تخمدان موش صحرایی ماده</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">را منتشر کرده­ایم. هدف این مطالعه مقایسه اثرات</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">مصرف کنترل شده کوتاه مدت 55-</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS</span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> با سوکروز و تاثیرات احتمالی آن بر بافت رحم و تخمدان</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">موش­های صحرایی ماده در مقایسه با مصرف بلند مدت آن بود</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">. </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal"></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt">روش بررسی</span></span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">:</span></span></span></span></i> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">طبق گایدلاین </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">OECD</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> (شماره 407)،</span></span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal">15سر موش صحرایی ماده به 3 گروه تقسیم شدند. گروه کنترل دریافت کننده آب مقطر، گروه دوم دریافتکننده سوکروز 75 % و گروه سوم دریافتکننده</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">HFCS-55</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> به میزان</span></span></span></span></i><i> </i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">g</span></span></span></i><i><span style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> 100/</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal">ml</span></span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.1pt"><span style="font-weight:normal"> 1 وزن بدن به شکل گاواژ (28 روز) بودند. الگوی دریافت انرژی، وزن، تغییرات رفتاری و شاخص های بیوشیمیایی و هیستوپاتولوژی در روز 29 مورد ارزیابی قرار گرفت. </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"><span style="font-weight:normal"></span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt">یافته </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt">ها:</span></span></span> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">هیچ گزارش مرگ و میر، تغییرات در الگوی انرژی، وزن و رفتار دیده نشد. از بین پروفایل لیپیدی و فاکتورهای بیوشیمیایی، صرفا سطح سرمی اسید اوریک و </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HDL</span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> در گروه های </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS-55</span></span></i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> و سوکروز نسبت به کنترل کاهش معنی­داری یافت. درگروه </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS-55</span></span></i><i> </i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">آپوپتوز سلولی در بافت رحم و احتقان بافت تخمدان ثبت شد که مشابه الگوی مطالعه 90روزه بود.</span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">نتیجه </span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">گیری</span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">:</span></span></span></i> <i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">نتایج این مطالعه در تطبیق با مطالعه 90 روزه، دلالت بر آسیب پذیری بافت رحم و تخمدان نسبت به فروکتوز در مقایسه با سوکروز دارد. خطر آسیب احتمالی</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">HFCS-55 </span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">بر رحم و تخمدان زنان</span></span></span></i><i> </i><i><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">نیاز به مطالعات تکمیلی دارد.</span></span></span></i></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Background</span></b><span style="font-size:11.0pt">: High-fructose corn syrup-55 (HFCS-55) is a common sweetener in the food industry. Recently, we have investigated and published the effects of uncontrolled long-term oral ingestion of 55-HFCS compared to sucrose on primary ovarian insufficiency in female rats. This study aimed to compare the effects of short-term controlled HFCS-55 administration with sucrose and its possible effects on the uterine and ovarian tissue of female rats compared to the long-term model. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Materials and methods</span></b><span style="font-size:11.0pt">: According to OECD guideline (No. 407), 15 female rats were divided into three groups. The control group received distilled water; the second group received sucrose 75%; the third group received HFCS-55; 1ml/100 g body weight, for 28 days by gavage. The pattern of energy intake, weight, behavioral changes, and indicators of biochemical and histopathology were evaluated on day 29. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Results</span></b><span style="font-size:11.0pt">: There were no reports of death, or changes in energy intake, weight, and behavior. Out of lipid profile and biochemical factors, serum levels of uric acid and HDL in the HFCS-55 and sucrose groups were significantly reduced compared to the control. In the HFCS-55 group, cell apoptosis was recorded in the uterine tissue (similar to the 90-day study), and ovarian tissue congestion was reported like in the 90-day study.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Conclusion</span></b><span style="font-size:11.0pt">: Results of our study compared to the 90-day study, indicate the vulnerability of the uterine and ovarian tissues caused by fructose. The possible damage risk of HFCS-55 on the uterus and ovary of women needs further epidemiological studies.</span></span></span></span></span></span><br>
شربت ذرت با فروکتوز بالا , 55-HFCS, ساکارز, سمیت, فروکتوز
High fructose corn syrup, HFCS-55, Sucrose, Toxicity, Fructose
29
39
http://tmuj.iautmu.ac.ir/browse.php?a_code=A-10-1152-2&slc_lang=fa&sid=1
Roya
Mirzaei
رویا
میرزائی
mirzaei.roya@gmail.com
100319475328460011028
100319475328460011028
No
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Islamic Azad University, Tehran, Iran
گروه سم شناسی داروشناسی، دانشکده داروسازی و علوم دارویی، علوم پزشکی تهران، دانشگاه آزاداسلامی ، تهران، ایران
Sepideh
Arbabi Bidgoli
سپیده
اربابی بیدگلی
sepideharbabi@yahoo.com
100319475328460011029
100319475328460011029
Yes
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Islamic Azad University, Tehran, Iran
گروه سم شناسی داروشناسی، دانشکده داروسازی و علوم دارویی، علوم پزشکی تهران، دانشگاه آزاداسلامی ، تهران، ایران
Roya
Khosrokhavar
رویا
خسروخاور
khosrokhavar_r@yahoo.com
100319475328460011030
100319475328460011030
No
Food and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health, Tehran, Iran
مرکز تحقیقات غذا و دارو، سازمان غذا و دارو، وزارت بهداشت- درمان و آموزش پزشکی، تهران، ایران
Shahram
Shoeibi
شهرام
شعیبی
shoeibi@yahoo.com
100319475328460011031
100319475328460011031
No
Food and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health, Tehran, Iran
مرکز تحقیقات غذا و دارو، سازمان غذا و دارو، وزارت بهداشت- درمان و آموزش پزشکی، تهران، ایران
Hamidreza
Ahmadi Ashtiani
حمیدرضا
احمد آشتیانی
ahmadihr@yahoo.com
100319475328460011032
100319475328460011032
No
Department of clinical Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
گروه بیوشیمی بالینی، دانشکده داروسازی و علوم دارویی، ، علوم پزشکی تهران، دانشگاه آزاداسلامی ، تهران، ایران