fa مطالعه آپوپتوزیس متعاقب تاثیر عصاره گل همیشه‌بهار در کارسینوم تجربی کولون موش صحرایی علوم تغذيه Nutrition Sciences <span style="font-weight: bold">Background:</span> In vitro studies have demonstrated the anticancer effect of Calendula officinalis extract on tumor cell line derived from colorectal cancers. The inhibition ranged from 70-100%. The aim of this study was to evaluate the apoptosis in epiththelial displastic colon cells following treated with Calendula officinalis extract. <br><span style="font-weight: bold">Materials and methods:</span> In this experimental study, 56 wistar male rats with age of 12 weeks and 200-300g weight were allocated into two equal groups of treatment and control. For induction of colorectal carcinoma, these two groups were given 1,2-dimethylhydrazine (40mg/kg), as subcutaneous injection, twice a week for two weeks. Treatment group also was treated with Calendula officinalis extract (200mg/kg/day) orally for 10 weeks. After 10 weeks, distal parts of colon tissue were biopsied in both groups and 3-4 micron tissue section was prepared through TUNEL staining method. <br> <span style="font-weight: bold">Results:</span> Immunohistopathological study reveals that apoptotic cells of displastic colon epithelial cells in treatment group were higher than control group. Mean difference between treatment and control groups were statistically significant (p<0.01). Conclusion: This study indicated that Calendula officinalis extract would be induced apoptosis of displastic colon cells in experimental colorectal carcinoma of rats. آپوپتوز، سرطان کولورکتال، گل همیشه‌بهار Apoptosis, Colorectal carcinoma, Calendula officinalis 1 4 http://tmuj.iautmu.ac.ir/browse.php?a_code=A-10-1-275&slc_lang=fa&sid=1 Yousef Doustar یوسف دوستار 10031947532846001232 10031947532846001232 Yes Dariush Mohajeri داریوش مهاجری 10031947532846001233 10031947532846001233 No Fatheme Fathiazad فاطمه فتحی‌آذر 10031947532846001234 10031947532846001234 No Ali Namvaran علی ناموران 10031947532846001235 10031947532846001235 No