2024-03-29T12:47:42+03:30
http://tmuj.iautmu.ac.ir/browse.php?mag_id=69&slc_lang=fa&sid=1
69-1884
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
The role and importance of DNA methylation in spermatogenesis process
Arezou
Nematollahi
MSc, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute f
Tavalaee
m.tavalaee@royan-rc.ac.ir
Atefeh
Rezaeian
Mohammad Hossein
Nasr- Esfahani
Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious consequences on development post fertilization. Dysregulation in epigenetic changes, especially sperm DNA methylation, may play an important role in the development of numerous diseases and has a negative effect on male fertility. The aim of this review study was to discuss about DNA methylation process and enzymes involved in this procedure and also the impact of environmental factors on the spermatogenesis process.
Materials and methods: A search was conducted according to keywords in databases such as Scopus, PubMed and Google Scholar. Then, all articles that met the inclusion criteria, between 1975 and 2017, were examined.
Results: Disorders in expression of DNA methyltransferases increase cellular oxidative stress and lifestyle can affect DNA methylation patterns during spermatogenesis and fertility potential in men.
Conclusion: As sperm DNA methylation is closely related to male infertility, it is important to understand underlying DNA methylation mechanisms in order to develop therapeutic strategies
Epigenetic
DNA methylation
Spermatogenesis
Male infertility.
2021
3
01
1
13
http://tmuj.iautmu.ac.ir/article-1-1884-en.pdf
10.52547/iau.31.1.1
69-1885
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
A review on the role of oral ginseng on erection dysfunction and fatigue in prostate cancer patients
Kamran
Asgharpour
Sepideh
Arbabi Bidgoli
sepideharbabi@gmail.com
Mehdi
Rajabi
Background: Current pharmacological and non-pharmacological treatment strategies for prostate cancer may control disease progression and increase the survival rates of patients but decreased quality of life is the most important concern of existing medical interventions. Erection dysfunction and fatigue are the most prevalent adverse effects of therapeutic procedures which impair the quality of life of patients from psychological and physiological viewpoints. We aimed in the first part of this review to explain and compare the adverse health effects of different therapeutic interventions and the level of their health impartments At the second part of this review we showed clinical evidence for risks and benefits of oral Ginseng supplement regimens in different stages of prostate cancer.
Materials and methods: To achieve these goals, human evidence and published clinical trials without time limit from databases until the end of 2019 were collected and qualitatively analyzed.
Results: The results showed that oral consumption of ginseng can improve erectile dysfunction, reduce fatigue and ultimately improve the quality of life of patients, but the duration of treatment, interactions and possible side effects of this supplement should also be considered.
Conclusion: Because of the relative effectiveness of this compound in continuous and long-term use, the role of ginseng in improving other aspects of quality of life in patients with prostate cancer, increasing life expectancy and drug resistance are other unknown aspects of this issue which needs further investigation.
Ginseng
Erection dysfunction
fatigue
Prostate cancer
2021
3
01
14
28
http://tmuj.iautmu.ac.ir/article-1-1885-en.pdf
10.52547/iau.31.1.14
69-1794
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
Strategies of vaccine production against COVID-19: when will an effective vaccine be produced?
Seyed Davar
Siadat
d.siadat@gmail.com
Ayoub
rahimi
Abolfazl
Fateh
afateh2@gmail.com
There is a strong consensus globally that production of an effective vaccine against SARS-CoV-2 is likely the most effective approach to sustainably controlling the COVID-19 pandemic. An unprecedented research effort and global coordination has resulted in a rapid development of vaccine candidates and initiation of trials. In this paper, we review vaccine candidate against COVID-19 and also challenges of vaccination have been explored in different region.
Vaccine
SARS-CoV-2
COVID-19.
2021
3
01
29
38
http://tmuj.iautmu.ac.ir/article-1-1794-en.pdf
10.52547/iau.31.1.29
69-1728
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
A review of the role of dopamine receptors and novel therapeutic strategies in non-small cell lung cancer (NSCLC)
Abbas
Jamshidi Avval
A_jamshidi@iau-tnb.ac.ir
Ghasem
Ahangari
ghah@nigeb.ac.ir
Lung cancer is a very aggressive and most deadly cancer in both men and women. Lung cancer is divided into two types of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is divided into 3 subgroups: adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large cell carcinoma (LCC). Dopamine is involved in controlling motions, cognition, emotions, memory and reward mechanisms within the brain. Dopamine receptors are divided into two D1 subfamilies, including D1 and D5, and D2 subfamilies, including D2, D3 and D4 receptors. There is an association between the expression of the D2 family of dopamine receptors and developing NSCLC. miRNAs are conserved molecules with 18-22 nucleotides. miR4301 is located in the first intron of the dopamine D2 receptor gene. Transfection of miR4301 into the A549 and QU-DB lung cancer cell lines reduces cell proliferation and increases apoptosis; so the use of miRNAs in combination with standard therapeutic strategies can improve the success of cancer treatment. In this review article, we evaluated the role of dopamine receptors and novel therapeutic strategies in NSCLC.
Lung cancer
Dopamine Receptor
miRNA
Apoptosis
2021
3
01
39
48
http://tmuj.iautmu.ac.ir/article-1-1728-en.pdf
10.52547/iau.31.1.39
69-1711
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
The impact of dust on public health and the realization of government civil liability in Iranian law
Yousof
Mohammadhoseini Hagivar
Sadraa1111@yahoo.com
Jamshid
Mirzaee
Mirzaiee.1348@yahoo.com
saydEbrahim
Mousavi
see.moosavi@gmail.com
The health of society is the result of God's grace to humanity. Due to the supervision of the rule of account, the government should observe and have a sense of prudence and required precautions, and also it must behave wisely. The necessity of public health is considered as a principle of social life. The trustees of nature sometimes not only don’t observe the protection of nature, but also are a threat to the health of nature and human society by their actions. Jurisprudence and law, as two inseparable links and complement each other, are tools to use the inspirational messages of Islam to tariff the scene of the creation of glory to human beings; otherwise oblige the harmful to repair the damage. Although particulate matter has long dominated the health of all, its increasing trend in recent decades can be the product of natural affairs or the result of human activities; this is the deduction of health to the present world. The result of the realization of civil liability for health is restoration to its former state, which is not properly codified in our law at the moment. For example, the payment of compensation to the Treasury Fund itself is a flawed reason for civil liability goals. In this case, support for the health of the community and methods of restoring it to its pre-injury state, despite having rich jurisprudence and tradition, and in order to eliminate and prevent the process of dust, have not been expressed to prevent the pollution of the community in the first place. In this situation, we cannot inherit it for the future, unless the laws of our country in the field of health and environmental protection are revised.
Civil liability
Islam
Community health
disaster
Compensation.
2021
3
01
49
69
http://tmuj.iautmu.ac.ir/article-1-1711-en.pdf
10.52547/iau.31.1.49
69-1726
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
Gene manipulation of human adipose-derived mesenchymal stem cells by miR-34a
Katayoun
Bahman Soufiani
k.bahman@modares.ac.ir
Ali Akbar
Pourfathollah
pourfa@modares.ac.ir
Mahin
Nikougoftar Zarif
nikougoftar@ibto.ir
Ehsan
Arefian
arefian@ut.ac.ir
Background: Safe and effective gene therapy is considered as one of the therapeutic goals in many diseases. Due to the important role of stem cells in cell therapy, this study aimed to produce human adipose-derived mesenchymal stem cells (hASCs) using the miR-34a overexpression.
Materials and methods: The hsa-mir-34a precursor sequence was cloned into the PCDH lentiviral vector. The recombinant vector and two helper vectors, i.e. psPAX and pMD2, were transferred into HEK-293T cell line by calcium phosphate method. Viral supernatant was collected and concentrated by ultracentrifuge. On the fourth day, transduced HEK-293 T cells were analyzed by flowcytometry. After the determination of viral concentration, hASC cells were transduced with condensed viruses. RNA extraction and cDNA synthesis were performed in order to assess miR-34a expression level by Real Time PCR.
Results: The hsa-mir-34a precursor sequence cloned into PCDH vector was confirmed by colony-PCR and DNA sequencing. Transduction of HEK-293T cells and hASCs were confirmed under fluorescent inverted microscope and flowcytometry. The assessment of miR-34a expression level in infected cells with recombinant virus showed that the expression ratio of miR-34a in the test group was significantly higher than the control group (P=0.001).
Conclusion: This study showed that lentiviral systems can be used to insert actopic genes like miR-34a into cells. It also showed that genetically manipulated stem cells can be used as a delivery system to deliver miR-34a or other genes.
Stem cells
Lentivirus
Transduction
Transfection
HEK-293T
miR-34a.
2021
3
01
70
78
http://tmuj.iautmu.ac.ir/article-1-1726-en.pdf
10.52547/iau.31.1.70
69-1671
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
Investigation of selective CDK4/6 inhibitor (Abemaciclib) cytotoxicity effects on human anaplastic thyroid cancer
Elaheh
Seyed Abutorabi
Abutorabi66@yahoo.com
Shiva
Irani
shi_irani@yahoo.com
Marjan
Yaghmaie
marjan_yaghmaie@yahoo.com
Seyed Hamidollah
Ghaffari
shghaffari_200@yahoo.com
Background: Thyroid cancer is one of the most common endocrine malignancies. Anaplastic thyroid cancer is a rare and dead full cancer among types of the thyroid cancer. Despite the conventional chemotherapy, a considerable number of the patients show developing chemo resistance. Therefore, there is a necessary need to find the novel therapeutic approaches in the anaplastic thyroid cancer patients. The aim of this study was to study anti-tumor effect of Abemaciclib on the anaplastic thyroid carcinoma cell lines.
Materials and methods: The human anaplastic thyroid cancer (SW1736 and C643) were cultured according to ATCC recommendations. The MTT assay was used to assess the chemo sensitivity of the cell lines in exposure to the desire concentration of Abemaciclib. Colony formation assay was used to determine the ability of the cell line colony formation in exposure to the drug. Quantitative real-time PCR was applied to analyze the mRNA expression of the apoptotic and anti-apoptotic genes.
Results: The cell viability and proliferation of the thyroid cancer cell lines were remarkably inhibited in doses of 10 and 20 μM of Abemaciclib (p<0.0001). Also, Abemaciclib reduced the number of the SW1736 and C643 colonies in doses of 1 and 2.5 μM, respectively. Moreover, Abemaciclib significantly reduced anti-apoptotic gene expression levels, including BCL2 and CMYC, and increased pro-apoptotic gene expression levels, including p21 and BAX (p<0.05).
Conclusion: Our study suggests that Abemaciclib could be used as a therapeutic agent in anaplastic thyroid cancer. Further laboratory and animal studies are needed and recommended to evaluate the exact molecular and clinical properties of Abemaciclib.
Anaplastic thyroid cancer
Inhibitor
Abemaciclib
2021
3
01
79
87
http://tmuj.iautmu.ac.ir/article-1-1671-en.pdf
10.52547/iau.31.1.79
69-1679
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
The comparison of the effect of dill extract and mefenamic acid on the duration of the postpartum pain: a randomized clinical trial
Fatemeh
Kheiriyat
F.Kheiriyat@gmail.com
Mitra
Tadayon Najafabadi
mitratadayon2000@yahoo.com
Parvaneh
Mousavi
mousavip2009@yahoo.com
Mohamad Hossain
Haghighizadeh
mhaghighy@yahoo.com
Foroogh
Namjoyan
namjoyan@yahoo.com
Background: Postpartum pain is one of the problems of the Post-delivery period. Prostaglandin inhibitors, such as nonsteroidal anti-inflammatory drugs, are commonly used to reduce pain, but may cause gastrointestinal side effects. In this study, the effect of dill essential oil and mefenamic acid on the duration of postpartum pain was compared.
Materials and methods: 108 multiparous women who had a normal vaginal delivery and suffered from the postpartum pain were recruited from Razi hospital of Ahvaz City. Subjects were randomly divided into two groups of 54: dill essential oil (1.5 mg / kg) and mefenamic acid (250 mg capsule), using a simple random sampling method. The magnitude of postpartum pain was measured by the Visual Analogue Scale two hours after birth. Patients experiencing the pain of 3.1 and more enrolled in the study. Both extract and mefenamic acid administered every 6 hours up to 4 times in case of constant pain. Following consumption of dill extract or mefenamic acid, the patient was asked to mention the duration of drug effect, the time of complete removal of the pain and the time of experiencing pain resumption. Statistical analysis was was done by t-test, Chi-square and repeated measure using SPSS Statistics V22.
Results: The duration of pain has decreased significantly over the time (39.2±3.21 and 32.07±1.89 min for the first and fourth intervention of dill extract, and 40.5±4.09 and 31.97±3.15 min for the first and fourth intervention of mefenamic acid) (P<0.001).The mean duration of drug effect following second and third intervention showed a significant reduction in the extract group (19.24±2.05 and 20.89±2.74 min respectively) compared to mefenamic acid group (34.22± 85.3 and 21.12±3.55 min respectively) (P<0.005).
Conclusion: It bseems that the onset of action of dill extract is faster than mefenamic acid; so extract can be used due to the lack of gastrointestinal side effects.
Anethum graveolens
Postpartum care
pain
Mefenamic Acid.
2021
3
01
88
96
http://tmuj.iautmu.ac.ir/article-1-1679-en.pdf
10.52547/iau.31.1.88
69-1723
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
Comparison of the effectiveness of logotherapy and treatment based on acceptance and commitment on the death anxiety, resilience and hopelessness of women with multiple sclerosis
Hadi
Smkhani Akbarinejhad
hadiakbarinejhad@yahoo.com
Ozra
Bayrampour
ozra.bayrampour75@gmail.com
Paria
Faroughi
faroughi66@gmail
Background: It seems that logotherapy and acceptance and treatment based on acceptance and commitment can affect on death anxiety, resilience and hopelessness in women with multiple sclerosis (MS). The purpose of this study was to compare the efficacy of logotherapy and treatment based on acceptance and commitment on death anxiety, resilience and hopelessness in pattern with MS.
Materials and methods: The method of this study was semi-experimental with pre-test, post-test and follow up with the control group. The population of this study consisted of all women with MS in Tabriz City who were members of MS Society of Tabriz in 2019. In total, 30 women were selected by purposive sampling method, and randomly divided into three groups of logotherapy and treatment based on acceptance and commitment and control group. Members of both experimental groups received their own treatment respectively in 8 sessions of 1.5 hours. Data were analyzed by repeated measures ANOVA and Bonferroni post hoc test.
Results: Logotherapy and treatment based on acceptance and commitment led to reduce death anxiety and hopelessness, and increase resilience compared to the control group in post-test of MS patients (P<0.001). In the follow-up phase, the effect of logotherapy and treatment based on acceptance and commitment on the death anxiety, resilience and hopelessness persisted (P<0.001). The effect of logotherapy and treatment based on acceptance and commitment on the death anxiety, resilience and hopelessness was not different at posttest and follow-up period.
Conclusion: Logotherapy and treatment based on acceptance and commitment are likely to reduce death anxiety, thereby they lead to better cope with disease, increase resiliency, and reduce hopelessness in patients with MS.
Logotherapy
Treatment based on acceptance and commitment
Death anxiety
Resilience
Hopelessness
Multiple Sclerosis.
2021
3
01
97
106
http://tmuj.iautmu.ac.ir/article-1-1723-en.pdf
10.52547/iau.31.1.97
69-1783
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
The pattern of improving the quality of internships courses in the Faculty of Paramedical Sciences, Islamic Azad University of Medical Sciences, Tehran Medical Branch
Narges
Montahey Abkenar
Hamid Reza
Aeasteh
Arastehhr@gmail.com
Akhtar
Jamali
Axtargamali@gmail.com
Background: Improving the quality of internship training requires continuous review of the status quo, identification of strengths and correction of weaknesses. In this regard, students' ideas, as an educational element, can be a way forward for future programs. The purpose of this study was to improve the quality of internship courses at the Faculty of Paramedicine, Islamic Azad University of Medical Sciences, Tehran Medical Branch.
Materials and methods: This study was carried out in a cross-sectional and qualitative manner. In the qualitative stage, the basic data approach was used. Theoretical coding was used to analyze the qualitative data.
Results: Regarding the present study, the quality improvement model of internship courses at the Faculty of Paramedical Sciences of Islamic Azad University of Tehran was evaluated using qualitative approach and exploratory design. To this end, using a qualitative approach and data coding, a model for improving the quality of internship courses was developed at the Faculty of Paramedicine of Islamic Azad University of Medical Sciences, Tehran Medical Branch.
Conclusion: The results of the pattern of improving the quality of internship courses in the department of paramedical sciences of Islamic Azad University of Tehran in the qualitative section showed that, in response to the circumstances of the adaptation, theoretical and clinical education, the attraction of specialist trainers, motivation, educational facilities, timing of the course students' information and evaluation were extracted. In response to the field of planning, increasing the number of hospitals was extracted. In response to intervening factors, financial constraints and a large number of students were extracted. In response to strategies, provision of educational facilities and interaction between clinical educators and educational professors was extracted and in response to outcomes, the outcomes were extracted for the hospital, patients, social and interns.
Theoretical coding
Internship courses
Paramedics
Quality improvement pattern
2021
3
01
107
120
http://tmuj.iautmu.ac.ir/article-1-1783-en.pdf
10.52547/iau.31.1.107
69-1760
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
The association of serum omentin-1 levels with biochemical parameters in patients with nonalcoholic fatty liver disease
Neda
Kolivand Saloki
Mahnaz
Mohammadi
mh_mohamadi@yahoo.com
Masoumeh
Nejdadali
Tahereh
Nagi
Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing due to the growing epidemics of obesity. Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. The aim of this study was to determine omentin-1 serum levels and its relationship with body mass index, fasting blood sugar and lipid profile.
Materials and methods: This case-control study was performed on 70 patients with non-alcoholic fatty liver disease and 70 participants as controls. Plasma levels of omentin 1 were measured by ELISA kit and other variables were determined by standard methods. Data were analyzed using SPSS version 20 software.
Results: Patients with non-alcoholic fatty liver presented significantly higher omentin levels compared to the controls (p<0.05). NAFLD patients had significantly higher levels of body mass index (BMI) and triglycerides, compared to healthy group (p-value<0.05). An inverse correlation was observed between omentin1with BMI, triglyceride, and LDL-C (p<0.05), but were positively associated with HDL‑C levels (p<0.05). We did find correlation between omentin‑1 with FBS in patients with non-alcoholic fatty liver (p<0.05).
Conclusion: The findings showed that omentin-1 serum levels were significantly different in patients with NAFLD when compared to controls. Omentin levels are correlated with BMI, LDL-C, and HDL-C.
omentin
Lipid profile
Non-alcoholic fatty liver disease
Anti-inflammatory
2021
3
01
121
127
http://tmuj.iautmu.ac.ir/article-1-1760-en.pdf
10.52547/iau.31.1.121
69-1730
2024-03-29
10.1002
Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
MEDICAL SCIENCES
1023-5922
2008-3386
10.61186/iau
2021
31
1
Association of placental location and neonatal weight in subjects attending to hospitals of Azad University of Tehran in 2018-2019
Kiana
Hosseinpour
Mina
Etminan-Bakhsh
metminanbakhsh@iautmu.ac.ir
Background: Fetal weight is a common index of health in neonates and determination of related factors would help to improve the conditions and outcomes. The aim of this study was to speculate the relationship between placental location and neonatal weight.
Materials and methods: We conducted an observational-prospective study on 87 pregnant women. Placental position was categorised by ultrasonography as anterior, posterior and lateral position. Demographic information, including age, early pregnancy weight, weight in the last week of pregnancy, height, gravid, parity, history of underweight in previous pregnancies and history of underweight in the husband family, was recorded in the checklist. Association of placental location with neonatal weight was noted in three groups.
Results: The highest birth weight was seen in cases with lateral placenta and the least weight was observed in anterior placenta cases and there was statistically significant association between placental location and neonatal weight.
Conclusion: Totally, according to the obtained results, it may be conducted that there is significant association between placental location and neonatal weight and the least weight was observed in anterior placenta.
Pregnancy
Placental location
Neonatal weight
Association
Iran
2021
3
01
128
133
http://tmuj.iautmu.ac.ir/article-1-1730-en.pdf
10.52547/iau.31.1.128