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جلد 31 شماره 1 صفحات 79-87 برگشت به فهرست نسخه ها
بررسی تاثیرات سمیت سلولی مهار کننده انتخابی CDK4/6 (Abemaciclib) بر سلول های انسانی سرطان تیروئید آناپلاستیک
الهه سید ابوترابی1، شیوا ایرانی1، مرجان یغمایی2، سید حمید الله غفاری 3
1- دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، گروه زیست شناسی، تهران، ایران
2- مرکزتحقیقات خون، انکولوژی و پیوند سلول بنیادی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران
3- مرکزتحقیقات خون، انکولوژی و پیوند سلول بنیادی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران ، shghaffari_200@yahoo.com
چکیده:   (407 مشاهده)
سابقه و هدف: سرطان تیروئید آناپلاستیک یکی از نادرترین و کشنده­ترین  نوع سرطان تیروئید به شمار می رود. علی­رغم رویکردهای درمانی معمول، مبتلایان به این سرطان،  اغلب مقاومت به عوامل شیمی درمانی را از خود نشان می­دهند. بنابراین، ارائه یک رویکرد درمانی جدید برای مبتلایان یک ضرورت در نظر گرفته می­شود. هدف از این مطالعه بررسی اثر ضد توموری داروی Abemaciclib بر رده­های سلولی سرطان تیروئید آناپلاستیک بود.
روش بررسی: رده های سلولی SW1736 و C643 کشت داده شدند. آزمون MTT برای بررسی حساسیت داروی Abemaciclib در دوزهای 0، 1، 5/2، 5، 10 و 20 میکرومولار در رده های سلولی و آزمون تشکیل کلونی برای بررسی توانایی تشکیل کلونی رده­های سلولی در مجاورت با دارو به کار برده شد. بیان ژن­های پیش برنده آپوپتوز و ضد آپوپتوزی توسط روش Real-time PCR کمی بررسی شد. 
یافته ­ها: داروی Abemaciclib به­طور معنی­داری بقا و تکثیر سلولی را در رده­های سلولی SW1736 و C643 در مقایسه با کنترل در دوز های 10 و 20 میکرومولار کاهش داد (0001/0p=). هم­چنین باعث مهار رشد کلونی رده­های سلولی SW1736 و C643  به ترتیب در دوزهای 1 و 5/2 میکرومولار شد. علاوه بر این این دارو سبب کاهش معنی­دار بیان ژن­های BCL2 و CMYC و افزایش بیان ژن­های P21 و BAX شد (05/0>p).
نتیجه ­گیری: مطالعه ما پیشنهاد می­کند که Abemaciclib می­تواند به عنوان یک عامل درمانی در سرطان تیروئید آناپلاستیک به کار رود. مطالعات آزمایشگاهی و حیوانی بیشتری برای بررسی روندهای مولکولی و بالینی دقیق داروی Abemaciclib مورد نیاز بوده و پیشنهاد می­شود.
واژه‌های کلیدی: سرطان تیروئید آناپلاستیک، مهار کننده، Abemaciclib
متن کامل [PDF 438 kb]   (212 دریافت)    
نيمه آزمايشي : تجربي | موضوع مقاله: انكولوژي
دریافت: 1398/5/21 | پذیرش: 1399/11/21 | انتشار: 1400/1/4
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Seyed Abutorabi E, Irani S, Yaghmaie M, Ghaffari S H. Investigation of selective CDK4/6 inhibitor (Abemaciclib) cytotoxicity effects on human anaplastic thyroid cancer. MEDICAL SCIENCES. 2021; 31 (1) :79-87
URL: http://tmuj.iautmu.ac.ir/article-1-1671-fa.html

سید ابوترابی الهه، ایرانی شیوا، یغمایی مرجان، غفاری سید حمید الله. بررسی تاثیرات سمیت سلولی مهار کننده انتخابی CDK4/6 (Abemaciclib) بر سلول های انسانی سرطان تیروئید آناپلاستیک. فصلنامه علوم پزشکی. 1400; 31 (1) :79-87

URL: http://tmuj.iautmu.ac.ir/article-1-1671-fa.html



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فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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