Background: Beta thalassemia is a common genetic disease in humans. This study aimed to assess various aspects of quality of life in patients with thalassemia major referred to Buali hospital in 2012-13.

Materials and methods: This cross-sectional analytical study was conducted on 40 patients with thalassemia major. Data were analyzed by statistical software SPSS V16 using Chi-square and t-test. The significance level was set at less than 0.05.

Results: 40 patients with mean (± standard deviation) age of 20.38±7.13 years were studied. 50% of patients were in the age range of 30-21 years. 22 patients (55%) were male. The mean age of the diagnosis was 7.5±1.4 months. Mean age of starting deferoxamine was 5.93±4.37 years. Data analysis revealed no significant relationship between age (P=0.246), gender (P= 0.259) and location of residency (P = 0.753) with quality of life.

Conclusion: There were the highest quality within the role of the physical evidence and lowest quality in the area of ​​patient's general health. Quality of caring was appropriate.

Keywords: Beta-thalassemia major, Care, Quality of life, Bu Ali Hospital.