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Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples
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Homayoun Jalali Tafti1   , Mehrdad Hashemi  2, Khalil Alimohammadzadeh3 |
1- MSC Student of Genetics, Tehran Medical Scienes, Islamic Azad University, Tehran, Iran
2- of Genetics, Department of Genetics, Tehran Medical Siences, Islamic Azad University. Tehran, Iran , mhashemi@iautmu.ac.ir
3- Associate Professor, Department of Health Services Management, North Tehran Branch, Islamic Azad University, Tehran, Iran ,Health Economics Policy Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran |
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Abstract: (3576952 Views) |
Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this study was to determine the expression of FGF14 in colorectal cancer tissue samples and adjacent healthy tissues.
Materials and methods: In this case-control study, 35 patients with colorectal cancer and adjacent tumor tissue were classified based on their clinical and pathological characteristics. The expression was studied by real time PCR reaction method.
Results: The relative expression levels of FGF14 in tumoral tissues were shown to be significantly increased compared with their adjacent normal tissues. There was significant correlation between the relative expression level of FGF14 in tumoral tissues and clinicopathological features, such as cancer staging, tumor size, and metastasis.
Conclusion: Increased expression of FGF14 in colorectal cancer tissue compared to the adjacent normal tissues is associated with the cancer progression and development relevant clinicopathological features. Therefore, it may play an important role in the pathophysiology of colorectal cancer. |
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| Keywords: Colorectal cancer, FGF14, Real-Time PCR, Gene expression, Tumor stage, Metastasis |
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Full-Text [PDF 484 kb]
(1504 Downloads)
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Semi-pilot: Experimental |
Subject:
Genetic
Received: 2018/10/31 | Accepted: 2019/01/6 | Published: 2019/09/28
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