:: دوره 31، شماره 3 - ( پائيز 1400 ) ::
جلد 31 شماره 3 صفحات 306-299 برگشت به فهرست نسخه ها
تاثیرتمرین تناوبی شدید و مصرف آلوئه ورا بر مقادیر آدیپونکتین و عملکرد سلول های بتا در موش های نر دیابتی
مهتاب سبزه پرور1 ، شاهین ریاحی ملایری 2، بهزاد دیوکان3
1- کارشناس ارشد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران
2- استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران ، shahinriyahi@yahoo.com
3- استادیار مدیریت ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد تهران شرق، دانشگاه آزاد اسلامی، تهران، ایران
چکیده:   (1853 مشاهده)
سابقه و هدف: تمرین ورزشی و استفاده از گیاهان دارویی ابزار کمکی در پیشگیری و درمان دیابت است. هدف از مطالعه حاضر  بررسی  تاثیر  هشت هفته تمرین تناوبی خیلی شدید و مصرف آلوئه ورا بر مقادیر آدیپونکتین و عملکرد سلول های بتا در موش های نر دیابتی بود.  
روش بررسی: در این مطالعه تجربی، 32 سر موش صحرایی نژاد ویستار (دامنه وزن 260-240 گرم و سن 12 هفته­ای) دیابتی شده با استرپتوزتوسین به طور تصادفی به چهار گروه (کنترل، تمرین، مکمل، تمرین + مکمل) تقسیم شدند. گروه­های تمرین به مدت 8 هفته و هر هفته 5 جلسه و هر جلسه 2 تا 6 دقیقه  تحت تاثیر تمرین تناوبی شدید با شدت 90 درصد VO2max قرار گرفتند. گروه­های دریافت کننده مکمل روزانه 300 میلی گرم آلوئه ورا به ازای هر کیلوگرم وزن بدن به مدت 8 هفته و پنج بار در هفته دریافت کردند. داده­ها با استفاده از روش آماری تحلیل واریانس یک راهه ارزیابی شد.   
یافته ­ها: هشت هفته تمرین تناوبی شدید همراه با مکمل آلوئه ورا منجر به افزایش معنی­دار آدیپونکتین و انسولین در موش های نر دیابتی شد (۵/۰>P). ولی در مقادیر گلوکز و عملکرد سلول­های بتا تفاوت معنی­داری مشاهده نشد (05/0<P).
نتیجه ­گیری: بر اساس یافته­های تحقیق حاضر به نظر می­رسد تمرین تناوبی شدید همراه با مکمل آلوئه ورا می­تواند به افزایش آدیپونکتین و انسولین منجر شود و در نتیجه به بهبود وکنترل دیابت کمک کند.
واژه‌های کلیدی: آدیپونکتین، آلوئه ورا، تمرین تناوبی، دیابت، عملکرد سلول های بتا
متن کامل [PDF 323 kb]   (743 دریافت)    
نيمه آزمايشي : تجربي | موضوع مقاله: فيزيولوژي
دریافت: 1399/7/7 | پذیرش: 1399/12/2 | انتشار: 1400/6/10
فهرست منابع
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60. Erfani MN, Bahrami M, Morovvati H, Najafzade H. Study the protective effect of Aloe Vera's on histological and histometric changes in testis of diabetic rats. Iran Veterinary J 2013; 9; 78-87. [In Persian]
61. Singh B, Saxena A. Surrogate markers of insulin resistance: A review. World J Diabetes 2010;1:36-47. [DOI:10.4239/wjd.v1.i2.36]
62. Rahman MM, Kwon HS, Kim MJ, Go HK, Oak MH, Kim DH. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. Biomed Pharmacother 2017; 92:606-614. [DOI:10.1016/j.biopha.2017.05.035]
63. Huang H, Iida KT, Sone H, Yokoo T, Yamada N, Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. J Endocrinol 2006;189:643-53. [DOI:10.1677/joe.1.06630]
64. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med (Maywood) 2007;232:184-94.
65. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 2005;90:5970-7. [DOI:10.1210/jc.2005-0261]
66. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007;56:1005-9. [DOI:10.1016/j.metabol.2007.03.009]
67. Zarekar M, Saghebjoo M, Foadodini M, Hedayati M. Combined Effect of Aerobic Training and Pistacia Athlantica Extract on GLUT-4 Protein Expression and Muscle Glycogen in Diabetic Rats. Iran J Endocrin Metab 2014; 16:245-253. [In Persian]
68. Mohammadi R, Matin Homaee H, Azarbayjani M, Baesi, K. he Effect of 12-Week Resistance Training Cardiac Hypertrophy, Glucose Level, Insulin, and Insulin Resistance Index in STZ-Induced Diabetic Rats. Qom Univ Med Sci J 2017;11:38-45. [In Persian]
69. Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, et al. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer 2011;18:357-69. [DOI:10.1530/ERC-10-0303]
70. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014;38:308-14. [DOI:10.1152/advan.00080.2014]
71. Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM. The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab 2005;90:4255-9. [DOI:10.1210/jc.2005-0019]
72. Eizadi M, Ravasi A A, Soori R, Baesi K, Choubineh S. Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide. Feyz 2017; 21:1-8. [In Persian] [DOI:10.17795/ajmb-34014]
73. Salehi O R, Hoseini A. The Effects of Endurance Trainings on Serum BDNF and Insulin Levels in Streptozotocin-Induced Diabetic Rats. Shafayeh Khatam 2017; 5:52-61. [In Persian] [DOI:10.18869/acadpub.shefa.5.2.52]
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