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:: Volume 32, Issue 1 (Spring 2022) ::
MEDICAL SCIENCES 2022, 32(1): 11-20 Back to browse issues page
Investigation on cross-linked nanomicrobial cellulose properties as modern wound dressing
Sahar Abbasi Geravand1, Ramin Khajavi 2, Mohammad Karim Rahimi3, Manouchehr Shamsini Ghiyasvand4, Amin Meftahi5
1- PhD Student, Department of Biomedical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran
2- Professor, Department of Polymer and Textile Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran , Khajavi@azad.ac.ir
3- Associate Professor, Department of Microbiology, Medical Faculty, Islamic Azad Medical University of Tehran, Tehran, Iran
4- Assistant Professor, Faculty of Biomedical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran
5- Assistant Professor, Department of Polymer and Textile Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (950 Views)
Background: Nanomicrobial cellulose is an important biopolymer with a three-dimensional structure that is produced by some microorganisms and has been widely used in medicine. One of the unique properties of microbial cellulose is its very high water absorption, which can be used to produce modern wound dressings. But after drying, it’s three-dimensional structure collapses and the amount of water reabsorption decreases. Accordingly, the aim of this project was to preserve the three-dimensional structure of nanomicrobial cellulose by networking it and improving the water reabsorption properties of this biopolymer. In addition, the cell viability, proliferation, and cell growth of the modified structure and untreated microbial cellulose were also studied.
Materials and methods: In this study, microbial cellulose was produced, purified, and neutralized using stationary culture. The samples were then treated with different concentrations of citric acid/sodium hypophosphite and crosslinked. Finally, the characteristics of treated and raw samples were studied by various tests including ATR-FTIR, MTT, SEM, water absorption and in vitro and in vitro tests.
Results: According to the results, it was found that the cross-linking operation prevents the collapse of the structure and not only does not cause toxicity, but in addition to increasing water uptake, it also increases viability, adhesion, and cell proliferation in the modified cellulose.
Conclusion: Cross-linked nanomicrobial cellulose has high potential as a modern wound dressing.
 
Keywords: Nanomicrobial cellulose, Cross-linking, Modern wound dressing, Cell viability, Proliferation, High water absorption
Full-Text [PDF 728 kb]   (333 Downloads)    
Semi-pilot: Experimental | Subject: Dermatology
Received: 2021/09/1 | Accepted: 2022/01/12 | Published: 2022/03/21
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Abbasi Geravand S, Khajavi R, Rahimi M K, Shamsini Ghiyasvand M, Meftahi A. Investigation on cross-linked nanomicrobial cellulose properties as modern wound dressing. MEDICAL SCIENCES. 2022; 32 (1) :11-20
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Volume 32, Issue 1 (Spring 2022) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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