:: Volume 32, Issue 3 (Fall 2022) ::
MEDICAL SCIENCES 2022, 32(3): 256-263 Back to browse issues page
Preparation and pharmaceutical evaluation of Mucoadhesive Buccal film extracts of petroselinum for pharyngitis symptoms
Mohsen Alvani1 , Rahim Bahri Najafi 2, Mahboobeh Mahmood3 , Seyed Saeed Naji Esfahani1 , Nilofar Fazel1
1- Student of Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
2- Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran , bahriv@Pharm.mui.ac.ir
3- Student of Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (941 Views)
Background: Recently, the mucosa has attracted attention due to its large arteries and high permeability for drug delivery. Due to the anti-inflammatory effect of parsley and easy access to this plant in Iran and the fact that the adhesive mucosa film is a new method with high performance and efficiency of drug transfer, this study was done to evaluate the effect of this plant on the pharyngitis by preparing an oral adhesive mucus film from parsley plant extract and then evaluating its pharmacological properties.
Materials and methods: Fast release films of parsley were made using hydroxypropyl methyl cellulosopropinyl alcohol polymers and the use of glycerin as plasticizer and casting method. Finally, the films are analyzed in terms of thickness, uniformity, amount of drug released and disintegration time with SPSS20 software.
Results: No bubbles, cracks, creases or wrinkles were seen in any of the films made of HPMC and PVA polymers. The difference in thickness measured in all films was less than 5%, and the thickness of the films was the same. Therefore, the drug introduced into the formulations has been spread evenly everywhere. No trace of the film remained in the mouth and the patients had good compliance.
Conclusion: Due to the rapid dissolution of the film, rapid release of the drug, ease of use and the appropriate effects of parsley in preventing inflammation, this formulation can be used for the elderly, children and those who have difficulty swallowing. Another advantage of this method is that it can reduce the metabolism of the drug in the first hepatic passage. As a result, this formulation is a good option for treating symptoms of pharyngitis.
 
Keywords: Petroselinum, Flavonoids, Apigenin, Buccal Drug Administration, Pharyngitis
Full-Text [PDF 533 kb]   (427 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2021/11/8 | Accepted: 2022/03/7 | Published: 2022/09/1
References
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24. Way T-D, Kao M-C, Lin J-K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 2004;279:4479-89. [DOI:10.1074/jbc.M305529200]
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26. Huy NT, Trang NV, Xuyen NT, Hong CT, Anh VTK, Thai VQ, et al. Studies on the antioxidant activity of apigenin, luteolin and nevadensin using DFT. Vietnam Journal of Science and Technology 2021;59:19-29. [DOI:10.15625/2525-2518/59/1/15472]
27. Harrison ME, Coombs MRP, Delaney LM, Hoskin DW. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp Mol Pathol 2014;97:211-7. [DOI:10.1016/j.yexmp.2014.07.006]
28. Marín I, Sayas-Barberá E, Viuda-Martos M, Navarro C, Sendra E. Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oils from Organic Fennel, Parsley, and Lavender from Spain. Foods 2016;5:18. [DOI:10.3390/foods5010018]
29. Shaikh R, Raj Singh TR, Garland MJ, Woolfson AD, Donnelly RF. Mucoadhesive drug delivery systems. J Pharm Bioallied Sci 2011;3:89-100. [DOI:10.4103/0975-7406.76478]
30. Punoševac M, Radović J, Leković A, Kundaković-Vasović T. A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley. Arch Pharm 2021;71:177-96. [DOI:10.5937/arhfarm71-30800]
31. Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev 2005;57:1556-68. [DOI:10.1016/j.addr.2005.07.001]
32. Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997;23:489-515. [DOI:10.3109/03639049709148498]
33. Ali J, Khar RK, Ahuja A. Formulation and characterisation of a buccoadhesive erodible tablet for the treatment of oral lesions. Pharmazie 1998;53:329-34.
34. Shin SC, Bum JP, Choi JS. Enhanced bioavailability by buccal administration of triamcinolone acetonide from the bioadhesive gels in rabbits. Int J Pharm 2000;209:37-43. [DOI:10.1016/S0378-5173(00)00542-1]
35. Bremecker KD, Strempel H, Klein G. Novel concept for a mucosal adhesive ointment. J Pharm Sci 1984;73:548-52. [DOI:10.1002/jps.2600730429]
36. Kohda Y, Kobayashi H, Baba Y, Yuasa H, Ozeki T, Kanaya Y, et al. Controlled release of lidocaine hydrochloride from buccal mucosa-adhesive films with solid dispersion. Int J Pharm 1997;158:147-55. [DOI:10.1016/S0378-5173(97)00241-X]
37. Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005;57:1666-91. [DOI:10.1016/j.addr.2005.07.003]
38. Lopez M, Sanchez-Mendoza I, Ochoa-Alejo N. Compartive study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) nym ex hill). J Agric Food Chem 1999;47:3292-6. [DOI:10.1021/jf981159m]
39. Yanardağ R, Bolkent Ş, Tabakoğlu-Oğuz A, Özsoy-Saçan Ö. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bulletin 2003;26:1206-10. [DOI:10.1248/bpb.26.1206]
40. valliolah HH, Ghanadi, Shariff B. Investigation of anti-inflammatory and analgesic effects of coriander plants. J Shahrekord Uni Med Sci 2003;5:8-15. [In Persian]
41. Farzaei MH, Abbasabadi Z, Ardekani MRS, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chin Med 2013;33:815-26. [DOI:10.1016/S0254-6272(14)60018-2]
42. Mahmood S, Hussain S, Malik F. Critique of medicinal conspicuousness of Parsley (Petroselinum crispum): a culinary herb of Mediterranean region. Pak J Pharm Sci 2014;27:193-202.
43. Al-Haadi AMH, Al Rahbi SS, Akhtar MS, Said S, Weli A, Al Riyami Q. Phytochemical screening, antibacterial and cytotoxic activities of Petroselinum crispum leaves grown in Oman. Iran J Pharm Sci 2013;9:61-5.
44. Maodaa SN, Allam AA, Ajarem J, Abdel-Maksoud MA, Al-Basher GI, Wang ZY. Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus). Behav Brain Funct 2016;12:1-16. [DOI:10.1186/s12993-016-0090-3]
45. Tang ELH, Rajarajeswaran J, Fung S, Kanthimathi M. Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells. J Sci Food Agric 2015;95:2763-71. [DOI:10.1002/jsfa.7078]
46. Mills S, Bone K, eds. Principles and practice of phytotherapy. Modern herbal medicine. London: Churchill Livingstone; 2000.
47. Sosa S, Balick M, Arvigo R, Esposito R, Pizza C, Altinier G, et al. Screening of the topical anti-inflammatory activity of some Central American plants. J Ethnopharmacol 2002;81:211-5. [DOI:10.1016/S0378-8741(02)00080-6]
48. Haidari F, Keshavarz SA, Shahi MM, Mahboob S-A, Rashidi M-R. Effects of parsley (Petroselinum crispum) and its flavonol constituents, kaempferol and quercetin, on serum uric acid levels, biomarkers of oxidative stress and liver xanthine oxidoreductase aactivity inoxonate-induced hyperuricemic rats. Iran J Pharm Res 2011;10:811.
49. Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system: A review. Int J Res Pharm Sci 2010;1:170-86.
50. Malke S, Shidhaye S, Desai J, Kadam V. Oral films-patient compliant dosage form for pediatrics. Int J Pediatr Neonatol 2010;11. [DOI:10.5580/44e]
51. Ikram M, Gilhotra N, Gilhotra RM. Formulation and optimization of muco adhesive buccal patches of losartan potassium by using response surface methodology. Adv Biomed Res 2015;4.
52. Way T-D, Kao M-C, Lin J-K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 2004;279:4479-89. [DOI:10.1074/jbc.M305529200]
53. de Menezes Epifanio NM, Cavalcanti LRI, Dos Santos KF, Duarte PSC, Kachlicki P, Ożarowski M, et al. Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract. Food Funct 2020;11:5346-56. [DOI:10.1039/D0FO00484G]
54. Huy NT, Trang NV, Xuyen NT, Hong CT, Anh VTK, Thai VQ, et al. Studies on the antioxidant activity of apigenin, luteolin and nevadensin using DFT. Vietnam Journal of Science and Technology 2021;59:19-29. [DOI:10.15625/2525-2518/59/1/15472]
55. Harrison ME, Coombs MRP, Delaney LM, Hoskin DW. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp Mol Pathol 2014;97:211-7. [DOI:10.1016/j.yexmp.2014.07.006]
56. Marín I, Sayas-Barberá E, Viuda-Martos M, Navarro C, Sendra E. Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oils from Organic Fennel, Parsley, and Lavender from Spain. Foods 2016;5:18. [DOI:10.3390/foods5010018]

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