The effect of phytochemical compounds on indicators of oxidative stress, inflammation and skeletal muscle damage caused by physical activity
| Mohsen Sahibi1 , Mohammad Ali Azarbayjani 2, Maghsoud Peeri3
|1- PhD student of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2- of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran , email@example.com
3- of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Abstract: (1042 Views)
|Physical activities are associated with increased production of reactive oxygen species. The production of reactive oxygen species is dependent of the intensity, duration and type of activity. Although the physiological amounts of reactive oxygen species are necessary to regulate cell reactions, their excessive production can cause numerous damages to the structure and function of cells and weaken physical function and endanger health. Although physical activity itself is a stimulus to increase the capacity of antioxidant defense, but in the case of intense and long exercises, the production of reactive oxygen species exceeds the capacity of antioxidant defense. In this situation, the use of exogenous antioxidant substances can be a good solution for the development of performance and physical health. Plants are abundant sources of antioxidant substances that can neutralize most active oxygen species caused by physical exercises, and then reduce inflammation and muscle damage induced by repeated muscle contractions, especially extrinsic contractions. Despite controversial findings due to differences in the methodologies of studies, their results generally confirm the effects of phytochemicals on reducing oxidative stress, inflammation, pain, muscle damage and improving physical performance. Based on these findings, it is recommended that people who undertake intense and long physical exercises should use plants containing phytochemicals in order to maintain and improve physical performance and develop health.
|Keywords: Intense physical activity, Oxidative stress, Inflammation, Phytochemicals
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Received: 2022/06/7 | Accepted: 2022/10/4 | Published: 2022/12/31
1. Halliwell B, Gutteridge JMC, Eds. Free Radicals in Biology and Medicine. New York: Oxford University Press; 2015.
2. Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012; 24: 981-90.
3. Zuo L, Zhou T, Pannell BK, Ziegler AC, Best TM. Biological and physiological role of reactive oxygen species--the good, the bad and the ugly. Acta Physiol (Oxf). 2015; 214: 329-48
4. Gandhi S, Abramov AY. Mechanism of Oxidative Stress in Neurodegeneration. Oxid Med Cell Longev 2012; 2012: 428010.
5. Majzunova M, Dovinova I, Barancik M, Chan JYH. Redox signaling in pathophysiology of hypertension. J Biomed Sci 2013; 20: 69.
6. Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res 2010; 44: 479-96.
7. Luc K, Schramm-Luc A, Guzik TJ, Mikolajczyk TP. Oxidative stress and inflammatory markers in prediabetes and diabetes. J Physiol Pharmacol 2019; 70.
8. Davalli P, Mitic T, Caporali A, Lauriola A, D'Arca D. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev 2016; 2016: 3565127.
9. Steinbacher P, Eckl P. Impact of oxidative stress on exercising skeletal muscle. Biomolecules 2015; 5: 356-77.
10. Radák Z, Asano K, Inoue M, Kizaki T, Oh-Ishi S, Suzuki K, et al. Superoxide dismutase derivative prevents oxidative damage in liver and kidney of rats induced by exhausting exercise. Eur J Appl Physiol Occup Physiol 1996; 72: 189-94.
11. Reid MB. Reactive Oxygen Species as Agents of Fatigue. Med Sci Sports Exerc 2016; 48: 2239-46.
12. Powers SK, Smuder AJ, Judge AR. Oxidative stress and disuse muscle atrophy: cause or consequence? Curr Opin Clin Nutr Metab Care 2012; 15: 240-5.
13. Park Y, Aminizadeh S, Lee J, Zarezadehmehrizi A, Najafipour H, Amiri-Deh Ahmadi M, et al. MitoQ supplementation improves oxygen uptake kinetic by reduced reactive oxygen species levels and altered expression of miR-155 and miR-181b. The FASEB Journal 2022; 36.
14. Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med 2008; 44: 142-52.
15. Wang L, Chen J, Xie H, Ju X, Liu RH. Phytochemical profiles and antioxidant activity of adlay varieties. J Agric Food Chem 2013; 61: 5103-13.
16. Shirvani H, Ghanbari-Niaki A, Rahmati-Ahmadabad S, Sobhani V. Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression. Int J Appl Exerc Physiol 2017; 6: 71-84.
17. Rahmati-Ahmadabad S, Azarbayjani MA, Broom DR, Nasehi M. Effects of high-intensity interval training and flaxseed oil supplement on learning, memory and immobility: relationship with BDNF and TrkB genes. Comparative Exercise Physiology 2021; 17: 273-83.
18. Barbosa AP, Silveira Gde O, de Menezes IA, Rezende Neto JM, Bitencurt JL, Estavam Cdos S, et al. Antidiabetic effect of the Chrysobalanus icaco L. aqueous extract in rats. J Med Food 2013; 16: 538-43.
19. Teles YCF, Souza MSR, Souza MFV. Sulphated Flavonoids: Biosynthesis, Structures, and Biological Activities. Molecules 2018; 23.
20. Peluso I, Miglio C, Morabito G, Ioannone F, Serafini M. Flavonoids and immune function in human: a systematic review. Crit Rev Food Sci Nutr 2015; 55: 383-95.
21. Mohammadi B, Anoosheh L, Rahmati-Ahmadabad S. Effect of 1-week Calendula officinalis consumption before high-intensity interval exercise on some delayed onset muscle soreness (DOMS) elements in male rowers. Comparative Exercise Physiology 2021; 17: 493-500.
22. Rezaee M, Hajiaghaee R, Azizbeigi K, Rahmati-Ahmadabad S, Helalizadeh M, Akbari M, Farzanegi P, Azarbayjani MA. The effect of essential oil of rosemary on eccentric exercise-induced delayed-onset muscle soreness in non-active women. Comparative Exercise Physiology 2020; 16: 129-36.
23. Naghavi-Azad E, Rahmati-Ahmadabad S, Amini H, Azizbeigi K, Helalizadeh M, Iraji R, et al. Effects of simultaneous intake of chamomile and ibuprofen on delayed-onset muscle soreness markers and some liver enzymes following eccentric exercise. German Journal of Exercise and Sport Research 2020; 50: 395-405.
24. Vakili S, Ghasemi F, Rahmati-Ahmadabad S, Amini H, Iraji R, Seifbarghi T, et al. Effects of vibration therapy and vitamin D supplement on eccentric exercise-induced delayed onset muscle soreness in female students. Comparative Exercise Physiology 2020; 16: 267-75.
25. Abdollahi S, Rahmati-Ahmadabad S, Abdollahi K, Gholami N, Ziyarati A, Nikbin S, et al. Phoenix dactylifera pollen does not affect eccentric resistance exercise-induced delayed-onset muscle soreness (DOMS) in female athletes. Sport Sciences for Health 2021; 17: 615-24.
26. Hotfiel T, Freiwald J, Hoppe MW, Lutter C, Forst R, Grim C, et al. Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics. Sportverletz Sportschaden 2018; 32: 243-50.
27. Dupuy O, Douzi W, Theurot D, Bosquet L, Dugué B. An Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review with Meta-Analysis. Front Physiol 2018; 9: 403.
28. Hody S, Croisier JL, Bury T, Rogister B, Leprince P. Eccentric Muscle Contractions: Risks and Benefits. Front Physiol 2019; 10: 536.
29. Konrad A, Kasahara K, Yoshida R, Yahata K, Sato S, Murakami Y, et al. Relationship between Eccentric-Exercise-Induced Loss in Muscle Function to Muscle Soreness and Tissue Hardness. Healthcare (Basel, Switzerland) 2022; 10.
30. Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H, et al. Oxidative stress and delayed-onset muscle damage after exercise. Free Radic Biol Med 2004; 37: 480-7.
31. Farias-Junior LF, Browne RAV, Freire YA, Oliveira-Dantas FF, Lemos T, Galvão-Coelho NL, et al. Psychological responses, muscle damage, inflammation, and delayed onset muscle soreness to high-intensity interval and moderate-intensity continuous exercise in overweight men. Physiol Behav 2019; 199: 200-209.
32. Cornish SM, Johnson ST. Systemic cytokine response to three bouts of eccentric exercise. Results Immunol 2014; 4: 23-29.
33. Torre MF, Martinez-Ferran M, Vallecillo N, Jiménez SL, Romero-Morales C, Pareja-Galeano H. Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review. Antioxidants (Basel) 2021; 10: 279.
34. Black CD, Herring MP, Hurley DJ, O'Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain 2010; 11: 894-903.
35. Dominguez-Balmaseda D, Diez-Vega I, Larrosa M, San Juan AF, Issaly N, Moreno-Pérez D, Burgos S, Sillero-Quintana M, Gonzalez C, Bas A, Roller M, Pérez-Ruiz M. Effect of a Blend of Zingiber officinale Roscoe and Bixa orellana L. Herbal Supplement on the Recovery of Delayed-Onset Muscle Soreness Induced by Unaccustomed Eccentric Resistance Training: A Randomized, Triple-Blind, Placebo-Controlled Trial. Front Physiol. 2020; 11 826. doi: 10.3389/fphys.2020.00826. PMC7396658.
36. Hoseinzadeh K, Daryanoosh F, Baghdasar PJ, Alizadeh H. Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness. Med J Islam Repub Iran 2015; 29 261.
37. Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, et al. Clinical trials on pain lowering effect of ginger: A narrative review. Phytother Res 2020; 34: 2843-56.
38. Khatami Sabzevar M, Haghighi A, Askari R. The Effect of Short-term Use of Chamomile Essence on Muscle Soreness in Young Girls after an Exhaustive Exercise. Journal of Medicinal Plants 2017; 16: 63-73.
39. Funakoshi-Tago M, Nakamura K, Tago K, Mashino T, Kasahara T. Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin. Int Immunopharmacol 2011; 11: 1150-9.
40. Ghasemzadeh Rahbardar M, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother 2017; 86: 441-9.
41. Kerksick CM, Kreider RB, Willoughby DS. Intramuscular adaptations to eccentric exercise and antioxidant supplementation. Amino Acids 2010; 39: 219-32.
42. Panza VS, Wazlawik E, Ricardo Schütz G, Comin L, Hecht KC, da Silva EL. Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition. 2008; 24: 433-42.
43. Jówko E, Sacharuk J, Balasińska B, Ostaszewski P, Charmas M, Charmas R. Green tea extract supplementation gives protection against exercise-induced oxidative damage in healthy men. Nutr Res 2011; 31: 813-21.
44. Herrlinger KA, Chirouzes DM, Ceddia MA. Supplementation with a polyphenolic blend improves post-exercise strength recovery and muscle soreness. Food Nutr Res 2015; 59: 30034.
45. Moradi Kelardeh B, Rahmati-Ahmadabad S, Farzanegi P, Helalizadeh M, Azarbayjani M-A. Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease. J Bodyw Mov Ther 2020; 24: 154-60.
46. McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K, Vingren JL, et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin 2016; 5: 72-8.
47. Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, et al. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. J Int Soc Sports Nutr 2014; 11: 31.
48. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol 2015; 115: 1769-77.
49. Morihara N, Nishihama T, Ushijima M, Ide N, Takeda H, Hayama M. Garlic as an anti-fatigue agent. Mol Nutr Food Res 2007; 51: 1329-34.
50. Farzanegi P, Abbaszadeh H, Farokhi F, Rahmati-Ahmadabad S, Hosseini SA, Ahmad A, et al. Attenuated Renal and Hepatic Cells Apoptosis Following Swimming Exercise Supplemented with Garlic Extract in Old Rats. Clin Interv Aging 2020; 15: 1409-18.
51. Su QS, Tian Y, Zhang JG, Zhang H. Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity. Eur J Appl Physiol 2008; 103: 275-83.
52. Esmaeelzadeh R, Azizbeigi K, Atashak S, Dehghan F, Feizolahi F, Azarbayjani MA, et al. Short-term influence of garlic supplementation therapy on oxidative stress markers following military physical activity: A preliminary study. Journal of Military and Veterans' Health 2021;29: 6-14.
53. McLeay Y, Barnes MJ, Mundel T, Hurst SM, Hurst RD, Stannard SR. Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J Int Soc Sports Nutr 2012; 9: 19.
54. Buchwald-Werner S, Naka I, Wilhelm M, Schütz E, Schoen C, Reule C. Effects of lemon verbena extract (Recoverben®) supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial. J Int Soc Sports Nutr 2018; 15: 5.
55. Panza VP, Diefenthaeler F, Tamborindeguy AC, Camargo Cde Q, de Moura BM, Brunetta HS, et al. Effects of mate tea consumption on muscle strength and oxidative stress markers after eccentric exercise. Br J Nutr 2016; 115: 1370-8.
56. Meamarbashi A, Rajabi A. Preventive effects of 10-day supplementation with saffron and indomethacin on the delayed-onset muscle soreness. Clin J Sport Med 2015; 25: 105-12.
57. Tsitsimpikou C, Kioukia-Fougia N, Tsarouhas K, Stamatopoulos P, Rentoukas E, Koudounakos A, et al. Administration of tomato juice ameliorates lactate dehydrogenase and creatinine kinase responses to anaerobic training. Food Chem Toxicol 2013; 61 9-13.
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Sahibi M, Azarbayjani M A, Peeri M. The effect of phytochemical compounds on indicators of oxidative stress, inflammation and skeletal muscle damage caused by physical activity. MEDICAL SCIENCES 2022; 32 (4) :347-355