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Alteration in capacity and function of proximal and distal convoluted tubules in kidney exposed by Molybdenum trioxide nanoparticles in female rats (Stereological technique)
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Simin Fazelipour    1, Mona Maleki2 , Tahereh Naji2 , Ali Kalantari-Hesari3 , Mohammad Babaei4 |
1- Department of Anatomy, Faculty of Tehran Medical Science, Islamic Azad University, Tehran, Iran , simin_fazelipour@yahoo.com
2- Department of Basic Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Islamic Azad University, Tehran, Iran
3- Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran
4- Department of Clinical Sciences, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran |
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Abstract: (619 Views) |
Background: One of the applications of molybdenum trioxide nanoparticles (MTNPs) is to use it as an antibacterial agent. The kidney is also one of the most important organs in the body to excrete waste products and regulate many blood factors. Duo to widespread use of MTNPs and the importance of the kidney, the aim of this study was to investigate this drug effect on kidney tubules.
Materials and methods: Thirty Wistar rats were divided into a control group, a sham group (receiving normal saline) and 3 experimental groups (receiving 50, 100, and 200 mg/kgBW MTNPs). The intraperitoneal injections were carried for 35 days. At the end of the treatment, the animals were euthanized after collecting blood samples. Then, their right kidney was removed and after tissue preparation, the samples were examined by stereology to determine changes in the volume, length, and surface area of tubules and epithelium height.
Results: The results showed that MTNPs caused significantly increases the volume of epithelium and the length and volume of the distal tubule compared to the control and sham group. Also, epithelium height and surface area of tubules and renal length in high levels of MTNPs were indicated significantly increases. These nanoparticles made changes most of stereological parameters which investigated in renal tubules and serum levels of creatinine.
Conclusion: Due to the widespread use of MTNPs in the industry as an antimicrobial as well as its adverse effects on renal tubules, the uncontrolled use of antimicrobial containing molybdenum trioxide should be avoided.
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| Keywords: Nephron, Renal damage, Antimicrobial, Renal tubules |
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Full-Text [PDF 418 kb]
(273 Downloads)
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Semi-pilot: Basic |
Subject:
Histology
Received: 2022/07/14 | Accepted: 2022/10/2 | Published: 2023/03/30
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| References |
1. Choi CHJ, Zuckerman JE, Webster P, Davis ME. Targeting kidney mesangium by nanoparticles of defined size. Proc Natl Acad Sci U S A 2011; 108: 6656-61.
2. Hester RL, Brown AJ, Husband L, Iliescu R, Pruett D, Summers R, Coleman TG. HumMod: a modeling environment for the simulation of integrative human physiology. Front Physiol 2011; 13: 12.
https://doi.org/10.3389/fphys.2011.00012
3. Smith PL, Buffington DA, Humes HD. Kidney epithelial cells. Methods Enzymol 2006; 419: 194-207.
https://doi.org/10.1016/S0076-6879(06)19009-6
4. Illyaskutty N, Sreedhar S, Kumar GS, Kohler H, Schwotzer M, Natzeck C, Pillai VM. Alteration of architecture of MoO 3 nanostructures on arbitrary substrates: growth kinetics, spectroscopic and gas sensing properties. Nanoscale 2014; 6: 13882-94.
https://doi.org/10.1039/C4NR04529G
5. Krishnamoorthy K, Veerapandian M, Yun K, Kim SJ. New function of molybdenum trioxide nanoplates: toxicity towards pathogenic bacteria through membrane stress. Colloids and Surfaces B: Biointerfaces 2013; 112: 521-4.
https://doi.org/10.1016/j.colsurfb.2013.08.026
6. Kaiser BN, Gridley KL, Ngaire Brady J, Phillips T, Tyerman SD. The role of molybdenum in agricultural plant production. Ann Bot 2005; 96: 745-54.
https://doi.org/10.1093/aob/mci226
7. Hosokawa S, Yoshida O. Clinical studies on molybdenum in patients requiring long-term hemodialysis. ASAIO J 1994; 40: M445-9.
https://doi.org/10.1097/00002480-199407000-00039
8. Czerwinski F. Current Trends in Automotive Lightweighting Strategies and Materials. Materials 2021; 14: 6631.
https://doi.org/10.3390/ma14216631
9. Pourali P, Yahyaei B. Biological production of silver nanoparticles by soil isolated bacteria and preliminary study of their cytotoxicity and cutaneous wound healing efficiency in rat. J Trace Elem Med Biol 2016; 34: 22-31.
https://doi.org/10.1016/j.jtemb.2015.11.004
10. Hong TK, Tripathy N, Son HJ, Ha KT, Jeong HS, Hahn YB. A comprehensive in vitro and in vivo study of ZnO nanoparticles toxicity. J Mater Chem B 2013; 1: 2985-92.
https://doi.org/10.1039/c3tb20251h
11. Yan G, Huang Y, Bu Q, Lv L, Deng P, Zhou J, et al. Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats. J Environ Sci Health A Tox Hazard Subst Environ Eng 2012; 47: 577-88.
https://doi.org/10.1080/10934529.2012.650576
12. Barbier O, Jacquillet G, Tauc M, Poujeol P, Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am J Physiol Renal Physiol 2004; 287: F1067-F75.
https://doi.org/10.1152/ajprenal.00120.2004
13. Reed RB, Ladner DA, Higgins CP, Westerhoff P, Ranville JF. Solubility of nano‐zinc oxide in environmentally and biologically important matrices. Environ Toxicol Chem 2012; 31: 93-99.
https://doi.org/10.1002/etc.708
14. Concolino G, Lubrano C, Ombres M, Santonati A, Flammia G, Di Silverio F. Acquired cystic kidney disease: the hormonal hypothesis. Urology 1993; 41: 170-5.
https://doi.org/10.1016/0090-4295(93)90175-A
15. Gaucher G, Poreba M, Ravenelle F, Leroux JC. Poly (N‐vinyl‐pyrrolidone)‐block‐poly (D, L‐lactide) as polymeric emulsifier for the preparation of biodegradable nanoparticles. J Pharm Sci 2007; 96: 1763-75.
https://doi.org/10.1002/jps.20833
16. Sadeghinezhad J, Nyengaard JR. Cat Kidney Glomeruli and Tubules Evaluated by Design‐Based Stereology. Anat Rec (Hoboken) 2019; 302: 1846-54.
https://doi.org/10.1002/ar.24144
17. Mehranjani MS, Noorafshan A, Momeni HR, Abnosi MH, Mahmoodi M, Anvari M, Hoseini SM. Stereological study of the effects of vitamin E on testis structure in rats treated with para-nonylphenol. Asian J Androl 2009; 11: 508-16.
https://doi.org/10.1038/aja.2009.29
18. Mohebbati R, Shafei MN, Beheshti F, Soukhtanloo M, Roshan NM, Anaeigoudari A et al. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi J Kidney Dis Transplant 2017; 28: 1270.
https://doi.org/10.4103/1319-2442.220880
19. Patanè FG, Liberto A, Maria Maglitto AN, Malandrino P, Esposito M, Amico F, et al. Nandrolone decanoate: use, abuse and side effects. Medicina 2020; 56: 606.
https://doi.org/10.3390/medicina56110606
20. Adeyemi OS, Adewumi I, Faniyan TO. Silver nanoparticles influenced rat serum metabolites and tissue morphology. J Basic Clin Physiol Pharmacol 2015; 26: 355-61.
https://doi.org/10.1515/jbcpp-2013-0092
21. Howell K, Hopkins N, McLoughlin P. Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues. Exp Physiol 2002; 87: 747-56.
https://doi.org/10.1113/eph8702477
22. Nyengaard JR. Stereologic methods and their application in kidney research. J Am Soc Nephrol 1999; 10: 1100-23.
https://doi.org/10.1681/ASN.V1051100
23. Hyvönen S, Peltonen L, Karjalainen M, Hirvonen J. Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly (L-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate. Int J Pharm 2005; 295: 269-81.
https://doi.org/10.1016/j.ijpharm.2005.02.026
24. Mallikarjuna K, Narasimha G, Dillip GR, Praveen B, Shreedhar B, Lakshmi CS, et al. Green synthesis of silver nanoparticles using Ocimum leaf extract and their characterization. Digest Journal of Nanomaterials and Biostructures. 2011; 6: 181-6.
25. Vimbela GV, Ngo SM, Fraze C, Yang L, Stout DA. Antibacterial properties and toxicity from metallic nanomaterials. Int J Nanomed 2017; 12: 3941.
https://doi.org/10.2147/IJN.S134526
26. Dwivedi AD, Gopal K. Plant-mediated biosynthesis of silver and gold nanoparticles. J Biomed Nanotechnol 2011;7:163-4.
https://doi.org/10.1166/jbn.2011.1250
27. Narayanan KB, Sakthivel N. Green synthesis of biogenic metal nanoparticles by terrestrial and aquatic phototrophic and heterotrophic eukaryotes and biocompatible agents. Adv Colloid Interface Sci 2011; 169: 59-79.
https://doi.org/10.1016/j.cis.2011.08.004
28. Zhang X, Yan S, Tyagi R, Surampalli R. Synthesis of nanoparticles by microorganisms and their application in enhancing microbiological reaction rates. Chemosphere 2011; 82: 489-94.
https://doi.org/10.1016/j.chemosphere.2010.10.023
29. Xia X, Hu Z, Marquez M. Physically bonded nanoparticle networks: a novel drug delivery system. J Control Release 2005; 103 :21-30.
https://doi.org/10.1016/j.jconrel.2004.11.016
30. Gules O, Yildiz M, Naseer Z, Tatar M. Effects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats. Biotech Histochem 2019; 94: 26-35.
https://doi.org/10.1080/10520295.2018.1493222
31. Tyl R, Myers C, Marr M, Thomas B, Keimowitz A, Brine D, et al. Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol Sci 2002; 68: 121-46.
https://doi.org/10.1093/toxsci/68.1.121
32. Berger FG, Watson G. Androgen-regulated gene expression. Ann Rev Physiol 1989; 51: 51-65.
https://doi.org/10.1146/annurev.ph.51.030189.000411
33. Wilson JD, Griffin JE. The use and misuse of androgens. Metabolism 1980; 29: 1278-95.
https://doi.org/10.1016/0026-0495(80)90159-6
34. Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, et al. Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci 2009; 108: 452-61.
https://doi.org/10.1093/toxsci/kfn246
35. Takahashi N, Boysen G, Li FY, Li Y, Swenberg JA. Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate. Kidney Int 2007; 71: 266-71.
https://doi.org/10.1038/sj.ki.5002033
36. He M, Ichinose T, Yoshida S, Ito T, He C, Yoshida Y, Arashidani K, Takano H, Sun G, Shibamoto T. PM2. 5‐induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells. J Appl Toxicol 2017; 37:1203-18.
https://doi.org/10.1002/jat.3482
37. Kone BC, Kaleta M, Gullans SR. Silver ion (Ag+)-induced increases in cell membrane K+ and Na+ permeability in the renal proximal tubule: reversal by thiol reagents. The Journal of membrane biology 1988; 102: 11-9.
https://doi.org/10.1007/BF01875349 [ DOI:10.1073/pnas.1103573108] |
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Fazelipour S, Maleki M, Naji T, Kalantari-Hesari A, Babaei M. Alteration in capacity and function of proximal and distal convoluted tubules in kidney exposed by Molybdenum trioxide nanoparticles in female rats (Stereological technique). MEDICAL SCIENCES 2023; 33 (1) :40-49 URL: http://tmuj.iautmu.ac.ir/article-1-2039-en.html
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