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The effect of statins on passive avoidance learning and neurogenesis in hippocampal CA1 and DG regions in NBM-lesioned wistar rats
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Parichehr Yaghmaei   1, Kazem Parivar2 , Nasim Alikhani3 |
1- PhD of Physiology , Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Sciences and Research Branch, Tehran, Iran , yaghmaei_p@yahoo.com
2- PhD of Developmental Biology , Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Sciences and Research Branch, Tehran, Iran
3- MSc, Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Sciences and Research Branch, Tehran, Iran |
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Abstract: (23659 Views) |
Background: Alzheimer's disease (AD) is a progressive neurodegenerative, age-related disease characterized by dementia and the loss of neuronal cells in the brain.
Materials and Methods: In this experimental study, the male wistar rat were studiedin five groups: control group: intact rat, sham group: NBM destructed rats by ibotenic acid and receiving salin for 14 days via gavage, experimental groups 1, 2 and 3: rat with destructed NBM and receiving 1mg/kg, simvastatin 1mg/kg, and atorvastatin and simvastatin each 0.5mg/kg via gavage, respectively, for 14 days. Learning and memory of all groups were examined by the shuttle box. In order to histological surveys, the brain were removed completely and transferred to formalin 10%.
Results: STL (duration of stay in the clear) was significantly increased in the experimental groups compared with control and sham groups (P<0.001). Statin caused significant decreasing (P<0.001) of TDC (duration of stay in the dark) in the experimental groups in comparison of control and sham groups. Histological studies of brain showed significant increasing of the granular cell in the DG area and also the significant increasing of the pyramidal cell CA1 area in group 2 (P<0.001) and group 3 (P<0.01).
Conclusion: This study showed that statins may result in improving learning and memory and repair of hypocamp in male Alzheimer rats. |
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| Keywords: Alzheimer\'s disease, Statins, Passive avoidance learning, Hypocamp, Male rat |
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Full-Text [PDF 264 kb]
(4648 Downloads)
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Semi-pilot: Experimental |
Subject:
Animal Biology
Received: 2012/06/26 | Published: 2012/06/15
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