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Effect of local application and injection of Cinnamomum zeylanicum on burn wound improvement in diabetic and non-diabetic male rats
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Ramesh Ahmadi1   , Naimeh Ghasemi 2 |
1- Biology Department, Faculty of Basic Sciences , Islamic Azad University , Qom Branch , Qom, Iran
2- MSc Student, Physiology Branch, Islamic Azad University, Qom Branch, Qom, Iran , Naimeh_Ghasemi@yahoo.com |
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Abstract: (8572 Views) |
Background: Burn wound, as a chemical and physical phenomenon, is a leading cause of mortality in the world. The aim of this study was to investigate the effect of Cinnamon zeylanicum extract on burn wounds in diabetic and non-diabetic male rats by local usage and injection method.
Materials and methods: In this experimental study, 48 Wistar male rats were divided into 2 groups of non-diabetic burn wound group and diabetic group which was divided itself into 4 subgroups. To create wounds, a hot iron seal placed on the skin. Testing duration was 21 days. At the end of every week, some photographs and measurement were taken.
Results: In diabetic control and local treatment group, a significant reduction was found on 14th day in wound surface in comparison of diabetic group that received extract. For local treatment, a significant reduction was observed in healthy treatment group on 7th, 14th and 21th days. Both healthy treatment and control group who received injection had a significant reduction on 14th and 7th days compared to healthy control group.
Conclusion: Application of cinnamon zeylanicum extracts would contribute to burn wound improvement and it seems more effective in non-diabetic group compared to diabetic group, and also the injection method was more effective. Perhaps, this is due to better absorption of Eugenol and Cinnamaldehyde in extract by injection rather than local treatment. |
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| Keywords: Cinnamon zeylanicum extract bark, Burn wound, Diabetes mellitus |
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Full-Text [PDF 232 kb]
(5117 Downloads)
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Semi-pilot: Experimental |
Subject:
Molecular Biology
Received: 2015/03/9 | Accepted: 2015/03/9 | Published: 2015/03/9
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