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:: Volume 25, Issue 3 (Fall 2015) ::
MEDICAL SCIENCES 2015, 25(3): 163-182 Back to browse issues page
lncRNAs roles in cancer occurrence
Mohammad Reza Noori-Daloii 1, Yeganeh Eshaghkhani2
1- PhD of Medical Molecular Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- PhD student of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (6598 Views)
Cancer is a complex condition in which gene expression is disrupted. Genetic factors involved in cancer pathology have been studied significantly. However, evidences have documented that a considerable fraction of susceptibility to cancer is not attributable to changes in protein coding sequences. Discovery and identification of a vast repertory of long noncoding RNAs (lncRNAs) with more than 200 nucleotides in human have been associated to unveiling their roles in tumorigenesis. Importance of lncRNAs, as either tumor suppressive or oncogenic agents, has been demonstrated in various common cancers. Recent studies indicate that several risk loci contributing to cancer pathogenesis are transcripted to lncRNAs which have critical roles in cancer incidence. Fundamental mechanisms of lncRNAs functions in a variety of gene expression levels involving epigenetic modification and transcriptional or post-transcriptional regulation, as well as interaction of these RNAs with other critical molecules such as DNA and some of proteins with definitive roles in cell fate have been described previously in detail by authors. Since a remarkable part of cancer pathogenesis has been reported in related to lncRNAs, the current review article discusses about association of some lncRNAs with specific tumors, effects of lncRNAs on cancer incidence and their importance in providing diagnostic and prognostic opportunities. Keywords: ncRNA, lncRNA, Cancer, Diagnosis, Prognosis.
Keywords: ncRNA, lncRNA, Cancer, Diagnosis, Prognosis
Full-Text [PDF 1031 kb]   (9162 Downloads)    
Semi-pilot: Review | Subject: Genetic
Received: 2015/07/7 | Accepted: 2015/09/14 | Published: 2015/09/21
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Noori-Daloii M R, Eshaghkhani Y. lncRNAs roles in cancer occurrence. MEDICAL SCIENCES. 2015; 25 (3) :163-182
URL: http://tmuj.iautmu.ac.ir/article-1-986-en.html


Volume 25, Issue 3 (Fall 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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