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Background: The effect of helicobacter pylori either in provoking or protecting GERD is unclear and the results of studies are conflicting. We aimed to study the effect of H.pylori eradication on GERD by 24-hour ph monitoring. Materials and methods: 14 patients with duodenal ulcer or erosive duodenitis without any endoscopic and clinical evidences of GERD were enrolled. 24-hour ph monitoring were performed before and 12 month after H-Pylori eradication. The score was based on DeMeester scoring system. H.Pylori was diagnosed by rapid urease test before eradication and by urea breath test (UBT) after eradication. Results: The mean age was 41.610.2 years. The mean scores of 24-hour ph monitoring were 6.84.3 and 5.43.9 before and after eradication, respectively. The differences were not statistically significant (NS). Epigastric pain changed significantly before and after the therapy (p<0.01). Conclusion: H.pylori eradication did not have any effect on scores of 24-hour esophageal ph monitoring. Epigastric pain significantly decreased after eradication.