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Background: Colorectal cancer in the world is located in the third position among common cancers in both sexes. It is the second cancer which has the most mortality .The incidence of this cancer in the last decades has transcended trend in our population. The aim of this study was comparison of 4-year survival between sporadic and hereditary colorectal cancer.
Materials and methods: In this descriptive-analytic study, 121 patients with colorectal cancer were collected including 61 patients with sporadic and 60 individuals with HNPCC who were referred to research cancer gastroenterology and liver diseases of Taleghani hospital during 2004-2008. Survival rate was estimated using the Kaplan Meier method and compared with log rank test. Multivariate analysis was performed using the Cox regression analysis.
Results: 4-year survival in sporadic colorectal cancer and HNPCC showed a significant difference. The rate of survival in HNPCC patients was 82.5%, while it was 56.4% (p=0.044) in sporadic colorectal cancer. Age of diagnosis in sporadic patients was higher than hereditary group. Odds ratio of sporadic colorectal cancer for tumor location was 2.93 (95%CI: 1.06-8.11) compared HNPCC (p=0.038).
Conclusion: The result of this study was compatible with the previous studies. The result showed that the rate of survival in patients with HNPCC is higher than sporadic cases.

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Background: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain. In this study, we examined all 10 exons to determine the most common mutations in MEFV gene as a single gene associated with FMF.
Materials and methods: In this basic study, 51 clinically diagnosed Iranian FMF patients referred to Taleghani hospital were studied. Peripheral blood was gained from them and genomic DNA was extracted according to phenol chloroform standard protocol. They were screened for the MEFV mutation using bidirectional sequencing and finally, the sequences were analyzed by related soft wares.
Results: Of 51 patients suspected to FMF, 24 (47.05%) were positive for mutation and 27 (52.95%) had no mutations. 14 patients had M694V mutation in exon10 including 4 homozygote mutation ,8 heterozygote and 4 compound heterozygote. Moreover, we could find 6 patients with M680I mutation and 2 individual (8.3%) with V721I mutation in exon 10. Only one person carried E148Q heterozygote mutation in exon 2.
Conclusion: Our finding were compatible with others investigation that M694V mutation is the most common mutation in different populations.