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Showing 2 results for Zarenezhad
Abdolmajid Ghasemian, Seyyed Khalil Shokouhi Mostafavi, Mahrokh Marzi, Mahsa Rostami Chijan, Maryam Kazemi, Elham Zarenezhad,
Volume 33, Issue 3 (Autumn 2023)
Abstract
Background: Helicobacter pylori (H. pylori) plays an indispensable role in the gastric cancer. Antibacterial and anti-biofilm effects of herbal medicines have been outlined in various studies.
Materials and methods: In this review study, the association of H. pylori with gastric cancer and antibacterial effects of herbal medicines was evaluated using previous published data. Key words included Helicobacter pylori, virulence factors, gastric cancer, thioredoxin-1 and herbal medicines. Searching engines included “Google”, “Google Scholar”, “PubMed”, “SCOPUS” and “Web of Science”.
Results: Virulence factors of the H. pylori alongside the host and environmental factors cause various gastric outcomes. Some of natural compounds have the potential of bactericidal effects, particularly those with multi-drug resistance and anti-biofilm effects against H. pylori. Antibiofilm agents have been mainly isolated from natural products, many of which are "secondary" metabolites and can be produced by microorganisms, such as phytochemicals, biosurfactants, antimicrobial peptides and microbial enzymes, etc.
Conclusion: This study revealed that H. pylori virulence factors such as recently identified thioredoxin-1 play substantial role in gastric ulcers and cancer. Herbal medicines contain various bioactive compounds which have potential antibacterial and anti-biofilm effects. Formulation of these compounds can enhance bioavailability and stability within the gastrointestinal tract.
Elham Zarenezhad, Abdolmajid Ghasemian, Aida Iraji, Mahsa Rostami Chijan, Maryam Kazemi, Elham Haghjoo,
Volume 34, Issue 1 (spring 2025)
Abstract
Background: 3,2,1 triazoles are an important class of five-membered heterocyclic compounds whose unique biological properties have made them an important class of chemical compounds. The biological activity of these compounds is known as anti-fungal, anti-bacterial, anti-tumor, anti-inflammatory, anti-depressant, anti-tuberculosis, anti-HIV, etc.
Materials and methods: In this research, first we synthesized new courcomin catalyst. We investigated synthesis of some 1,2,3 triazol derivatives and evaluated their anti-bacterial and anti-fungal effects. After synthesis and purification of some 1,2,3-triazol compound, the inhibitory effect of compounds against fungal (Candida albicans, Aspergillus niger) and against bacterial (Staphylococcus arueus and Escherichia coli) was evaluated.
Results: It was found that compound (3): 1-(4-bromobenzyl)-1H-1,2,3-triazol-4-ol exhibited the best antifungal activities. Also this compound showed good activity against Staphylococcus areus as a Gram-positive bacteria.
Conclusion: According to the results, it seems that the use of recombinant substance 3 as a new compound with acceptable antimicrobial properties can be considered
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