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Background: Anti- fatigue and physical stamina effects of many plants have been evaluated so far, and some are accepted in clinical use. In the present research, the anti-fatigue effects of Commiphora Mukul resin extract were studied on male rats.
Materials and methods: A total of 40 male rats were divided into 3 experimental and one control groups. The resin extract (15, 30, 50 mg/kg) was orally administrated to experimental rats for two weeks. Forced swimming test (FST) was performed on days 1, 7 and 14 and blood samples were collected for measurement of Glc, TP, CK, LDH and BUN using an auto-analyser.
Results: A significant reduction in immobility time in FST was observed in resin extract-fed groups, as compared with the control (p<0.01). In addition, levels of CK and LDH decreased significantly (p<0.01), the content of Glc was significantly increased, and the amount of BUN and TP did not show any significant changes.
Conclusion: Commiphora Mukul Resin (Gugulipid), a well-known anti-hyper-lipidemic and anti-inflammatory drug, showed the potential of anti-fatigue effect in the present study.