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Background: The aim of this study was to assess the frequency of symptoms of depression, general anxiety, obsessive compulsive and phobia in interictal phase among patients suffering from epilepsy.
Materials and methods: This cross sectional observational study was performed on 137 outpatients referred to neurology clinic of Imam Hossein hospital in 2004. All patients were in the interictal phase. Demographic and epilepsy variables and a questionnaire including items asking about depression, general anxiety, obsessive compulsive and phobia of SCL-90-R (symptoms check list-90- revised) was completed.
Results: Relative frequency of depression, general anxiety, obsessive compulsive, and phobia was 55.4%, 44.9%, 55.8% and 23.2%, respectively. Phobia symptoms were associated with lower educational level (p=0.029), unemployment (p=0.013) and older age (p=0.013). The symptoms of obsessive compulsive (p=0.041) and general anxiety (p=0.044) were associated with older age. Different psychiatric symptoms were not correlated with sex, amount of drug use, marital status and the duration of the disease or type of epilepsy.
Conclusion: Our findings highlighted that depression and obsessive compulsive symptoms in the first grade and general anxiety and phobia in the second grade are among the causes of morbidity among epileptic patients. Psychiatric symptoms are suspected to be higher in older, unemployed, and less educated epileptic patients. A close cooperation between neurologists and psychiatrists is necessary in the approach to the patients with epilepsies.

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Background: Group acceptance and commitment therapy, as a treatment method, has direct and two- way correlation with reducing health anxiety. The aim of the present study was to evaluate the efficacy of group acceptance and commitment therapy on health anxiety of woman with epilepsy with three- month follow-up.
Materials and methods: The present study was a controlled experimental study with pre-test and post-test design. Among the female patients with epilepsy admitted to the health centers of Kermanshah, 30 persons were selected through purposeful sampling and randomly assigned to experimental and control groups (15 in experimental and 15 in control groups). Both groups responded to health anxiety scale, at the pre-test stage. In the experimental group, the group acceptance and commitment therapy intervention were conducted for 8 sessions of 90-minute. After completing the session, post-test and three months after the intervention, follow-up was conducted on two experimental and control groups. Data analysis was done using spss19 by descriptive tests and ANOVA with repeated measure.
Results: ANOVA with repeated measure analysis showed that the group acceptance and commitment therapy had a significant positive effect on decreasing health anxiety. Findings were also preserved in the follow-up phase.
Conclusion: The results of research showed that of group acceptance and commitment therapy intervention can be used as an efficient way to decrease health anxiety in patients with epilepsy.

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Background: Temporal lobe epilepsy is a chronic neurological disorder characterized by spontaneous seizures, learning and memory deficiency, loss of neurons, mossy fiber sprouting and tissue apoptosis. This study was to investigate the effect of NOP receptor agonist (MCOPPB) and antagonist (SB612111) on seizure and cognitive dysfunction and histological studies in experimental model of temporal lobe epilepsy in male rat.
Materials and methods: in this study, 50 male rats were divided into six groups, including sham, epileptic, valperoic treated epileptic, NOP receptor agonist and antagonist treated epileptic. Finally, seizure behavior, short-term (Y-maze) and long-term (shuttle box) memory, GFAP value and also histologic finding (Nissel, Tim and Apoptosis staining) were evaluated.
Results: Kinic acid induced seizures associated with significant seizure behavior, impairment of learning and memory and tissue damage. Pretreated epileptic rats with NOP receptor agonist decreased seizure attacks, but did not improve memory. Administration of NOP antagonist was not effective on the seizure behavior, but contribute to improve the memory and learning abilities following treatment. Also, administration of NOP agonist and antagonist increased neuron count, reduced increased sprouting of mossy fibers, cell death and the activity of astrocytes in the hippocampus.
Conclusion: pre-treatment of epileptic rets with NOP receptor agonist and antagonist reduced seizures attacks and improved short-term spatial memory and tissue damage in rats.

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Background: Patients with epilepsy are involved in many psychological problems; so in addition to medical interventions, psychological interventions should also be considered in their recovery plan. The aim of this study was to determine the effectiveness mindfulness-based stress reduction therapy (MBSRT) on sleep quality and psychological well-being of women with epilepsy.
Materials and methods: This study was a semi-experimental study with a pretest-posttest control group design. The statistical population of the research included all women with epilepsy in Tabriz City who were members of the Epilepsy Association of this city in 2023. In total, 30 people were selected by purposive sampling method, and randomly divided into two groups (15 people each). Members of the experimental group received their treatment in eight sessions of 1.5 hours; however, the control group did not receive any treatment. Data were analyzed using ANOVA with repeated measures.
Results: In the pretest, mean and standard deviation of MBSRT for sleep quality was 17.67±2.52 and for psychological well-being was 43.93±5.94; and in the control group sleep quality was 16.87±2.03 and for psychological well-being was 46.33±6.30 (p>0.05). At post-test, MBSRT increased their sleep quality and psychological well-being (p<0.001). At the follow-up stage, the effect of this treatment was lasting (p<0.001).
Conclusion: Mindfulness-based stress reduction therapy can possibly increase sleep quality and psychological well-being in women with epilepsy.