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Background: DOX is one of the most common drugs used to treat different types of cancer, including ‎testicular cancer. The aim of this study was to evaluate the effect of ethanol extract of ginger on ‎spermatogenesis in rats. ‎ Materials and methods: In this experimental study, 56 male rats Wistar were randomly divided into 6 ‎groups of 8 animals control, the sham and experimental group 1 receiving doxorubicin (mg/kg.bw 3) ‎experimental 2 and 3 receiving ginger extract (500 , 1000 mg/ kg. bw ) and experimental 4 and 5 ‎received a ginger extract (500 , 1000 mg/ kg. bw ) + doxorubicin. The rats were fed extract daily, one ‎hour after doxorubicin injection, for four weeks. DOX (3mg/kg) was administered once a week ‎intraperitoneally. Some sperm parameters, such as the number, viability, morphology and mobility were ‎examined using Eosin-Ngrozin staining. ‎ Results: A significant decrease in body weight, sperm count, sperm motility, viability was observed in ‎drug-DOX-treated rats compared with the control group. The reduction in the group treated with DOX ‎with ginger 500 and 1000 mg/ kg significantly was offset compared with DOX. ‎ Conclusion: Ginger is able to have protective effect on sperm parameters in adult male rat induced by ‎Doxorobicin.‎ Keywords: Ginger, Doxorubicin, Body weight, Testes, Sperm parameters, Rat.‎