Medical Sciences Journal of Islamic Azad University
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران
MEDICAL SCIENCES
Medical Sciences
http://tmuj.iautmu.ac.ir
1
admin
1023-5922
2008-3386
000
10.61186/iau
000
1023-5922
000
fa
jalali
1401
12
1
gregorian
2023
3
1
33
1
online
1
fulltext
fa
اثر کوانزیم Q10 بر شاخصهای استرس اکسایشی و آسیب بافت بیضه در موشهای صحرایی به دنبال مسمومیت تحریکی با مونوسدیم گلوتامات
The effect of coenzyme Q10 on oxidative stress parameters and testicular tissue damage in rats following monosodium glutamate induced excitatory intoxication
زيست شناسي جانوري
Animal Biology
تجربي
Experimental
<br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">سابقه و هدف</span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:Nazanin"><span style="font-weight:normal">:</span></span></span></i> <i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">مونوسدیم گلوتامات (</span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">MSG</span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">) به عنوان یک بهبود دهنده طعم غذا شناخته شده است که میتواند اثرات منفی بر سیستم تولید مثل مردان بگذارد. مطالعه حاضر به منظور بررسی نقش محافظتی کوانزیم </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">Q10 (Co-Q10)</span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> در برابر استرس اکسیداتیو ناشی از </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal">MSG</span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal"> و تغییرات هیستوپاتولوژیک در بافت بیضه موش صحرایی انجام شد. </span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="font-weight:normal"></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.3pt">روش بررسی</span></span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.3pt"><span style="font-weight:normal">:</span></span></span></span></i> <i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">در این مطالعه تجربی، تعداد 40 سر موش صحرایی نر بالغ نژاد ویستار به صورت تصادفی در 4 گروه شامل کنترل، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG+Q10-10</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG+Q10-20</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> قرار گرفتند. گاواژ </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG (gr/kg 3)</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و تزریق </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Co-Q10</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> در دو دوز 10 و 20 میلی گرم بر کیلوگرم (درون صفاقی) به مدت 4 هفته صورت گرفت. فعالیت آنزیم کاتالاز (</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">CAT</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">)، سوپراکسید دیسموتاز (</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">SOD</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">) و گلوتاتیون پراکسیداز (</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">GPx</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">) به روش الایزا و سطح مالون دیآلدهید (</span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MDA</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">) به روش تیوباربیتوریک اسید در بافت بیضه انجام شد. سپس ارزیابی هیستولوژیک بافت بیضه در گروههای مطالعه انجام شد.</span></span></span></span></i><i> </i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.3pt"><span style="font-weight:normal"></span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt">یافته </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt">ها:</span></span></span> <i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">مونو سدیم گلوتامات باعث افزایش سطح پراکسیداسیون لیپیدی به موازات کاهش قابل توجهی در فعالیت آنزیمهای </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">CAT</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">SOD</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">GPX</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> در بافت بیضه شد. تجویز </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Co-Q10</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> در گروه های دریافت کننده </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> باعث کاهش پراکسیداسیون لیپیدی، افزایش فعالیت آنزیمهای </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">CAT</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">SOD</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> و </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">GPx</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> شد. از طرفی، </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Co-Q10</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> به طور قابل توجهی تغییرات هیستوپاتولوژیک ناشی از </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> را در بافت بیضه موشهای صحرایی تحت درمان کاهش داد.</span></span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span style="font-weight:bold"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">نتیجه </span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin"">گیری</span></span><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="font-weight:normal">:</span></span></span></i> <i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal">مکمل </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">Co-Q10</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> میتواند سمیت بیضهای ناشی از </span></span></span></span></i><i><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.2pt"><span style="font-weight:normal">MSG</span></span></span></i><i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""><span style="letter-spacing:-.2pt"><span style="font-weight:normal"> را تا حد زیادی بهبود بخشد و استرس اکسیداتیو بر بافتهای بیضه را کاهش دهد. </span></span></span></span></i><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Koodak""><span style="font-weight:normal"></span></span></span></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Background</span></b><span style="font-size:11.0pt">: Monosodium glutamate (MSG) is known as a food flavor enhancer that can adversely affect the male reproductive system. The present study was investigated the protective effect of coenzyme Q10 (Co-Q10) against MSG-induced oxidative stress and histopathological changes in rat testicular tissue. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Materials and methods</span></b><span style="font-size:11.0pt">: In this experimental study, 40 adult male Wistar rats were randomly divided into 4 groups including control, MSG, MSG + Q10-10 and MSG + Q10-20. MSG gavage (3 gr / kg) and Co-Q10 injection were performed at doses of 10 and 20 mg / kg (intraperitoneally) for 4 weeks. The activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was determined by ELISA and malondialdehyde (MDA) by thiobarbituric acid techniques in testicular tissue. Then, histological evaluation of testicular tissue was performed in the groups. </span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Results</span></b><span style="font-size:11.0pt">: Monosodium glutamate increased the level of lipid peroxidation along with a significant decrease in the activity of CAT, SOD and GPX enzymes in testicular tissue. Co-administration of Co-Q10 in MSG groups reduced lipid peroxidation, increased the activity of CAT, SOD and GPx enzymes. On the other hand, Co-Q10 significantly reduced MSG-induced histopathological changes in the testicular tissue of treated rats.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:11.0pt"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:11.0pt">Conclusion</span></b><span style="font-size:11.0pt">: Co-Q10 supplementation can ameliorates MSG-induced testicular toxicity and reduce oxidative stress on testicular tissues.</span></span></span></span></span></span><br>
مونوسدیم گلوتامات, استرس اکسایشی, بیضه, موش صحرایی
Monosodium glutamate, Oxidative stress, Testis, Rat
11
20
http://tmuj.iautmu.ac.ir/browse.php?a_code=A-10-1549-1&slc_lang=fa&sid=1
Gholam Ali
Heidari
غلامعلی
حیدری
heidari.teacher@gmail.com
100319475328460011020
100319475328460011020
No
PhD Candidate in Animal Physiology, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
گروه زیست شناسی، دانشکده علوم، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
Nematollah
Razmi
نعمت الله
رزمی
doctorrazmi@gmail.com
100319475328460011021
100319475328460011021
Yes
of Biochemistry, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
گروه زیست شناسی، دانشکده علوم، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
Seyed Ebrahim
Hosseini
سید ابراهیم
حسینی
ebrahim.hossini@yahoo.com
100319475328460011022
100319475328460011022
No
r of Physiology, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
گروه زیست شناسی، دانشکده علوم، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران