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:: Volume 25, Issue 4 (winter 2015) ::
MEDICAL SCIENCES 2015, 25(4): 249-256 Back to browse issues page
LncRNAs: new approach in cancer therapy
Mohammad Reza Noori-Daloii1, Yeganeh Eshaghkhani2
1- PhD of Medical Molecular Genetics, School of Medicine, Tehran University of Medical Science, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- PhD Student of Medical Genetics, School of Medicine, Tehran University of Medical Science, Tehran, Iran
Abstract:   (6067 Views)

LncRNAs are non-coding transcripts with more than 200 nucleotides in length which interact to other molecules through their particular molecular structures and affect on numerous molecular processes. Key functions of lncRNAs in a great variety of cell pathways have been significantly studied. These molecules are expressed in many various cell types, but their decreased or increased expression has been reported in different diseases, especially cancer. Published papers have introduced lncRNAs and their crucial roles in primary steps of tumorigenesis, tumor development and apoptosis. lncRNAs importance in cancer occurrence is so remarkable that level measurement of some of them may be a considerable aid in diagnosis or prognosis of related cancer. Furthermore, a variety of new therapeutic approaches are innovated based on inhibition or enhancement of lncRNAs functions for alleviation disease severity however, they are conceivable only in research concept. In the current article, these approaches and their related molecular basis are conveyed by the use of the newest reliable resources.

Keywords: long non-coding RNAs, Cancer, Tumorogenesis, Treatment.

Keywords: long non-coding RNAs, Cancer, Tumorogenesis, Treatment
Full-Text [PDF 306 kb]   (4629 Downloads)    
Semi-pilot: Review | Subject: Genetic
Received: 2015/07/7 | Accepted: 2015/09/14 | Published: 2015/12/20
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Noori-Daloii M R, Eshaghkhani Y. LncRNAs: new approach in cancer therapy. MEDICAL SCIENCES 2015; 25 (4) :249-256
URL: http://tmuj.iautmu.ac.ir/article-1-1020-en.html


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Volume 25, Issue 4 (winter 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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